ArticleJournal of biomedical optics2019
Hyperspectral imaging in the spatial frequency domain with a supercontinuum source.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Python-controlled multimodal UV-VIS hyperspectral imaging system.Journal of biomedical optics · 2026Article
- Real-Time Structural Illumination with Hyperspectral Images: A Tunable Projection-Capture Synchronizer for Three-Phase Demodulation on Embedded Heterogeneous Computing Platforms.Sensors (Basel, Switzerland) · 2026Article
- Machine reading and recovery of colors for hemoglobin-related bioassays and bioimaging.Science advances · 2025Article
- Monte Carlo simulations and phantom modeling for spatial frequency domain imaging of surgical wound monitoring.Journal of biomedical optics · 2023Article
- Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer's disease and neurological injury.Neurophotonics · 2023Review
- Multimodal hyperspectral fluorescence and spatial frequency domain imaging for tissue health diagnostics of the oral cavity.Biomedical optics express · 2021Article
- Dual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring.Biomedical optics express · 2021Article
- A paintable phosphorescent bandage for postoperative tissue oxygen assessment in DIEP flap reconstruction.Science advances · 2020Article
- Applications of compressive sensing in spatial frequency domain imaging.Journal of biomedical optics · 2020Article
- Handheld multispectral imager for quantitative skin assessment in low-resource settings.Journal of biomedical optics · 2020Article
- Special Section Guest Editorial: Special Section on Spatial Frequency Domain Imaging.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We introduce a method for quantitative hyperspectral optical imaging in the spatial frequency domain (hs-SFDI) to image tissue absorption (μa) and reduced scattering (μs') parameters over a broad spectral range. The hs-SFDI utilizes principles of spatial scanning of the spectrally dispersed output of a supercontinuum laser that is sinusoidally projected onto the tissue using a digital micromirror device. A scientific complementary metal-oxide-semiconductor camera is used for capturing images that are demodulated and analyzed using SFDI computational models. The hs-SFDI performance is validated using tissue-simulating phantoms over a range of μa and μs' values. Quantitative hs-SFDI images are obtained from an ex-vivo beef sample to spatially resolve concentrations of oxy-, deoxy-, and met-hemoglobin, as well as water and fat fractions. Our results demonstrate that the hs-SFDI can quantitatively image tissue optical properties with 1000 spectral bins in the 580- to 950-nm range over a wide, scalable field of view. With an average accuracy of 6.7% and 12.3% in μa and μs', respectively, compared to conventional methods, hs-SFDI offers a promising approach for quantitative hyperspectral tissue optical imaging.
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