ArticleInfection & chemotherapy2019
Clinical and Laboratory Predictors associated with Complicated Scrub Typhus.
Article in Infection & chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Clinical features and risk factors for severe pediatric scrub typhus in Liangshan Prefecture, China: A retrospective cohort study.BMC pediatrics · 2026Article
- Analysis of the Epidemiological Characteristics and Risk Factors for Severe Progression of Scrub Typhus in the Dali Region of China.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Application of artificial intelligence models in the identification of severe scrub typhus.Frontiers in artificial intelligence · 2026Article
- Incidence of Scrub Typhus in Rural South India.The New England journal of medicine · 2025Observational
- Analysis of outer membrane protein fromBioinformation · 2025Article
- Predictors of mortality in scrub typhus: A hospital-based study.Journal of family medicine and primary care · 2024Article
- Spontaneous splenic rupture associated with scrub typhus: a case report.Infectious diseases of poverty · 2024Article
- Predictors of Severity of Scrub Typhus in Children Requiring Pediatric Intensive Care Admission.Journal of pediatric intensive care · 2022Article
- Clinical characteristics and risk factors for severe scrub typhus in pediatric and elderly patients.PLoS neglected tropical diseases · 2022Article
- Rickettsiosis with Pleural Effusion: A Systematic Review with a Focus on Rickettsiosis in Italy.Tropical medicine and infectious disease · 2022Review
- Epidemiological and Clinical Features of Patients with Scrub Typhus - Guangzhou City, Guangdong Province, China, 2012-2018.China CDC weekly · 2021Article
- The epidemiology, diagnosis and management of scrub typhus disease in China.Human vaccines & immunotherapeutics · 2021Article
- Clinical significance of hypoalbuminemia in patients with scrub typhus complicated by acute kidney injury.PloS one · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScrub typhus, a mite-borne disease caused by bites of MATERIALS AND
methodsThis study retrospectively reviewed the medical records of patients diagnosed with scrub typhus.
resultsA total of 710 patients were enrolled and 43.9% of them were elderly patients. The number of patients with complicated scrub typhus was 168 (23.7%) and the most common complication of severe scrub typhus was hepatic dysfunction (10.7%) followed by pneumonia (7.2%), acute kidney injury (4.9%) and shock (2.4%). Blood urea nitrogen ≥20 mg/dL, adenosine deaminase (ADA) ≥100 IU/L, pulmonary edema or pleural effusion, lactate dehydrogenase ≥500 U/L, alkaline phosphatase ≥400 IU/L, ferritin ≥500 ng/mL and absence of skin rash were independently associated with severe scrub typhus. There was no significant difference in the incidence of complicated scrub typhus between elderly and non-elderly patients. Absence of skin rash, pulmonary edema, pleural effusion, serum creatinine ≥1.5 mg/dL, total bilirubin ≥1.5 mg/dL, ADA ≥100 IU/L and ferritin ≥500 ng/mL were significantly associated with a longer hospitalization (≥10 days).
conclusionThe several independent predictors of complicated scrub typhus were identified in this study. Absence of skin rash, the increased levels of serum ADA and ferritin were identified as the predictors of complicated scrub typhus, which were also associated with a prolonged hospitalization.
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