Evidence map›Paper›PMID 31270993›Full record

ArticleInfection & chemotherapy2019

Thromboembolism in

Hyerim Ha, Ki Hwan Kim, Jin Hyun Park, Jung Kyu Lee, Eun Young Heo, Jin Soo Kim, Deog Kyeom Kim, In Sil Choi, Hee Soon Chung, Hyo Jeong Lim

Open access · goldAbstract read
In one paragraph

Article in Infection & chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hyerim HaDivision of Hematology and Medical Oncology, Department of Internal medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-8889-144X
Ki Hwan KimDivision of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea. floresta405@gamil.com.ORCID https://orcid.org/0000-0002-9001-6537
Jin Hyun ParkDivision of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-1078-4139
Jung Kyu LeeDivision of Pulmonology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-5060-7255
Eun Young HeoDivision of Pulmonology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-3803-4903
Jin Soo KimDivision of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-2636-2352
Deog Kyeom KimDivision of Pulmonology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-9379-8098
In Sil ChoiDivision of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-8494-584X
Hee Soon ChungDivision of Pulmonology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-3595-5777
Hyo Jeong LimDepartment of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-7313-1461
Seoul National University · KRSNUH SMG-SNU Boramae Medical Center · KRSeoul National University Hospital · KRVeterans Health Service Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis is associated with hypercoagulation; however, there are few reports of cases thromboembolism and tuberculosis at the same time in the real world. The purpose of this study was to report the incidence and clinical course of thromboembolism in patients diagnosed with tuberculosis. MATERIALS AND

methodsWe retrospectively analyzed the data of patients who were diagnosed with both tuberculosis and thromboembolism including pulmonary thromboembolism (PTE) or deep vein thrombosis (DVT) at Seoul National University Boramae Medical Center from January 2000 through March 2015.

resultsAmong the 7905 tuberculosis patients, 49 (0.6%) exhibited PTE, DVT, or both at or after the time of tuberculosis diagnosis. All patients treated for tuberculosis started with isoniazid, ethambutol, rifampicin, and pyrazinamide. Eight patients were switched to treatment with second-line medication because of resistance or adverse events. About half of the patients (n = 21, 44.7%) had thrombosis at the time of tuberculosis diagnosis. Of 48 patients treated for thromboembolism, 36 received warfarin. A total of 20 patients improved symptom caused by thrombosis, and 10 patients were confirmed cure by image study such as computed tomography or doppler ultrasonography. Eight patients who were treated with warfarin had persistent thrombosis. Five patients (10.2%) experienced major bleeding that required hospitalization. All of these bleeding events were associated with warfarin therapy.

conclusionsCareful attention to PTE/DVT is needed at the time of diagnosis of tuberculosis and during anti-tuberculosis therapy. Warfarin therapy administered with anti-tuberculosis medication requires frequent monitoring to prevent major bleeding.

Indexed as

Deep vein thrombosisPulmonary embolismThromboembolismTuberculosis

Identifiers

PMID31270993
PMCPMC6609750
OpenAlexW2954541273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.