Evidence map›Paper›PMID 31270960›Full record

ReviewCancer medicine2019

Improved characterization of the relationship between long intergenic non-coding RNA Linc00152 and the occurrence and development of malignancies.

Jiasheng Xu, Jingjing Guo, Yangkai Jiang, Yujun Liu, Kaili Liao, Zhonghua Fu, Zhenfang Xiong

Open access · goldAbstract readReview
In one paragraph

Review in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The impact of STAiR18 on multiple myeloma survival rates.Journal of translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiasheng XuDepartment of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Jingjing GuoDepartment of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yangkai JiangDepartment of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yujun LiuQueen Mary College of Nanchang University, Nanchang, China.
Kaili LiaoDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Zhonghua FuDepartment of Burns, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Zhenfang XiongDepartment of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China.ORCID 0000-0003-2062-9204
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linc00152, located on chromosome 2p11.2, is a long intergenic non-coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing tumor cell proliferation, invasion, metastasis, and apoptosis. Additionally, linc00152 contributes to the carcinogenesis of several cancers, including gastric cancer, liver cancer, hepatocellular carcinoma, gallbladder cancer, clear cell renal cell carcinoma, and colorectal cancer, by disturbing various signaling pathways (eg PI3K/AKT, mTOR, IL-1, and NOTCH 1 signaling pathways). High linc00152 expression levels are associated with chemoresistance as well as poor prognosis and shorter survival. Continual advances made in the relevant research have indicated that linc00152 may be useful as a new tumor molecular biomarker, applicable for tumor diagnosis, targeted therapy, and prognosis assessment. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications.

Indexed as

Drug Resistance, NeoplasmBiomarkers, TumorDisease ProgressionGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansNeoplasmsPrognosisRNA, Long NoncodingBiomarkers, Tumorlong non-coding RNA Linc00152, humanRNA, Long Noncodinglinc00152long non-coding RNAmalignant tumor

Identifiers

PMID31270960
PMCPMC6712457
OpenAlexW2955716343

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.