ArticleClinical and experimental immunology1988
Predominance of IgA deposits in glomeruli of Schistosoma mansoni infected mice.
Article in Clinical and experimental immunology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Kidney biomarkers in tropical infections: an update.Pathogens and global health · 2020Review
- Immunopathogenesis of experimental IgA nephropathy.Springer seminars in immunopathology · 1994Review
- Immunopathology of Schistosoma mansoni infection.Clinical microbiology reviews · 1989Review
- Glomerulopathy associated with schistosomiasis mansoni.Jornal brasileiro de nefrologiaReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We found that IgA is predominant among the immune deposits in the renal glomeruli of mice infected with Schistosoma mansoni, and thus conducted an analysis of the deposition of different immunoglobulin isotypes in the glomeruli throughout the course of infection in mice. Both immunofluorescent and immunoperoxidase methodologies were employed and compared. The abundance of S. mansoni antigens and the isotypes of antibodies to these antigens were examined in the sera and kidney eluates of mice during the course of infection and the results were related to the findings of immunohistopathology. Our observations suggest that at least some immune complexes form in situ in the glomeruli of infected mice and support a possible role of liver damage in the pathogenesis of renal disease in schistosomiasis. Intestinal mucosal immune responses to schistosome antigens may be important in the evolution of renal disease. In addition, the relevance of the murine model to human schistosomal nephropathy is questioned.
Indexed as
Identifiers
3127090PMC1541649W165034055What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.