Evidence map›Paper›PMID 31270754›Full record

SynthesisSports medicine (Auckland, N.Z.)2019

The Impact of Different Types of Exercise Training on Peripheral Blood Brain-Derived Neurotrophic Factor Concentrations in Older Adults: A Meta-Analysis.

Nastasia Marinus, Dominique Hansen, Peter Feys, Raf Meesen, Annick Timmermans, Joke Spildooren

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 13 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 13 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nastasia MarinusFaculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Center, Hasselt University, Agoralaan, Building A, 3590, Diepenbeek, Belgium. nastasia.marinus@uhasselt.be.ORCID http://orcid.org/0000-0002-4903-2439
Dominique HansenFaculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Center, Hasselt University, Agoralaan, Building A, 3590, Diepenbeek, Belgium.
Peter FeysFaculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Center, Hasselt University, Agoralaan, Building A, 3590, Diepenbeek, Belgium.
Raf MeesenFaculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Center, Hasselt University, Agoralaan, Building A, 3590, Diepenbeek, Belgium.
Annick TimmermansFaculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Center, Hasselt University, Agoralaan, Building A, 3590, Diepenbeek, Belgium.
Joke SpildoorenFaculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Center, Hasselt University, Agoralaan, Building A, 3590, Diepenbeek, Belgium.
Hasselt University · BEJessa Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs the prevalence of neurodegenerative diseases (such as dementia) continues to increase due to population aging, it is mandatory to understand the role of exercise for maintaining/improving brain health.

objectivesTo analyse the impact of aerobic, strength and combined aerobic/strength exercise training on peripheral brain-derived neurotrophic factor (BDNF) concentrations in older adults (minimum age 60 years).

methodsThis meta-analysis adhered to PRISMA guidelines. Inclusion criteria were: (i) studies with subjects aged ≥ 60 years, (ii) completing a single exercise bout or an exercise programme, with (iii) measurements of blood BDNF in the periphery; (iv) with comparison between (a) an intervention and control group or (b) two intervention groups, or (c) pre- and post-measurements of an exercise intervention without control group. Studies with specific interest in known chronic co-morbidities or brain diseases affecting the peripheral and/or central nervous system, except for dementia, were excluded.

resultsIn general, peripheral blood BDNF concentrations increased significantly after a single aerobic/strength exercise bout (Z = 2.21, P = 0.03) as well as after an exercise programme (Z = 4.72, P < 0.001). However, when comparing the different types of exercise within these programmes, the increase in the peripheral BDNF concentrations was significant after strength training (Z = 2.94, P = 0.003) and combined aerobic/strength training (Z = 3.03, P = 0.002) but not after (low-to-moderate intense) aerobic exercise training (Z = 0.82, P = 0.41).

conclusionsBased on current evidence, to increase the peripheral blood BDNF concentrations in older adults, strength training and combined aerobic/strength training is effective. More studies are needed to examine the impact of aerobic exercise training.

Indexed as

ExerciseBrain-Derived Neurotrophic FactorHumansMiddle AgedRandomized Controlled Trials as TopicResistance TrainingBDNF protein, humanBrain-Derived Neurotrophic Factor

Identifiers

PMID31270754
OpenAlexW2954347305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.