Evidence map›Paper›PMID 31270728›Full record

ArticleBiomechanics and modeling in mechanobiology2020

Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.

Jungsil Kim, Austin J Cocciolone, Marius C Staiculescu, Robert P Mecham, Jessica E Wagenseil

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. The functional role of the extracellular matrix in inflammatory bowel disease associated gut fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  2. Article
  3. Article
  4. Elastin, arterial mechanics, and stenosis.American journal of physiology. Cell physiology · 2022
    Review
  5. Passive biaxial mechanical behavior of newborn mouse aorta with and without elastin.Journal of the mechanical behavior of biomedical materials · 2022
    Article
  6. Influence of shape-memory stent grafts on local aortic compliance.Biomechanics and modeling in mechanobiology · 2021
    Article
  7. Developmental origins of mechanical homeostasis in the aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jungsil KimDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA.
Austin J CoccioloneDepartment of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Marius C StaiculescuDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA.
Robert P MechamDepartment of Cell Biology and Physiology, Washington University, St. Louis, MO, USA.
Jessica E WagenseilDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA. jessica.wagenseil@wustl.edu.ORCID http://orcid.org/0000-0001-7972-448X
Washington University in St. Louis · US

Funding

ASSEMBLY OF LUNG ELASTINR37HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 2000 to 2009
$4.1M
ASSEMBLY OF LUNG ELASTINR01HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 1995 to 2019
$3.6M
VESSEL STIFFENING, HYPERTENSION, AND VASCULAR EXTRACELLULAR MATRIXR01HL105314 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P., WAGENSEIL, JESSICA · 2010 to 2018
$3.2M
BIOMECHANICAL FACTORS IN CONGENITAL VASCULAR DISEASER01HL115560 · NHLBI · WASHINGTON UNIVERSITY · PI WAGENSEIL, JESSICA · 2012 to 2015
$1.5M
National Science Foundation 1662434NHLBI NIH HHS HL-105314NHLBI NIH HHS HL-115560NHLBI NIH HHS HL-53325NHLBI NIH HHS R01 HL053325NHLBI NIH HHS R01 HL105314NHLBI NIH HHS R01 HL115560NHLBI NIH HHS R37 HL053325
6 · The paper itself

Abstract

Deposition of elastin and collagen in the aorta correlates with increases in blood pressure and flow during development, suggesting that the aorta adjusts its mechanical properties in response to hemodynamic stresses. Elastin knockout (Eln

Indexed as

Stress, MechanicalAnimalsAnimals, NewbornAortaBiomechanical PhenomenaBlood PressureCaptoprilDesmosineElastinExtracellular Matrix ProteinsGene Expression RegulationHeart RateHeart VentriclesHydroxyprolineMice, KnockoutMyocytes, Smooth MuscleCaptoprilDesmosineElastinExtracellular Matrix ProteinsHydroxyprolineReceptors, AngiotensinRNA, MessengerAngiotensin-converting enzymeAngiotensin IIArterial developmentArterial mechanicsArterial remodelingCaptoprilElastinExtracellular matrix

Identifiers

PMID31270728
PMCPMC6940555
OpenAlexW2955869203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.