Trial reportJournal of gastroenterology2019
Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria.
Trial report in Journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The trial behind it
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Who cites it
25 citing papers in PubMed.
- Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model.Scientific reports · 2021Trial
- Clinical and CT Imaging Features of Chronic Pancreatitis: A Cross-Sectional Study From Vietnam.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Article
- Decoding the Natural History of Alcohol-Related Recurrent Acute Pancreatitis and Progression to Early Chronic Pancreatitis: Clinical, Biochemical, and Imaging Insights from a Single-Center Retrospective Study in France.Journal of clinical medicine · 2025Article
- Advancing the Diagnosis and Treatment of Early Chronic Pancreatitis Through Innovation in Imaging and Biomarker Profiling-A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Article
- Early Chronic Pancreatitis Findings by Endoscopic Ultrasonography (EUS) in Asymptomatic Patients with Pancreas Divisum.Diagnostics (Basel, Switzerland) · 2025Article
- Surgical outcomes of the Frey procedure for chronic pancreatitis: correlation between preoperative characteristics and the histological severity of pancreatic fibrosis.Surgery today · 2023Article
- From cradle to grave: seamless management of chronic pancreatitis but consider the special requests for children.Hepatobiliary surgery and nutrition · 2023Article
- Review
- Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis-A Single Center Comparative Analysis.Diagnostics (Basel, Switzerland) · 2023Article
- Evidence-based clinical practice guidelines for chronic pancreatitis 2021.Journal of gastroenterology · 2022Review
- St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.Journal of translational medicine · 2022Article
- The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition.Journal of clinical medicine · 2022Article
- Article
- Comprehensive review of diagnostic modalities for early chronic pancreatitis.World journal of gastroenterology · 2021Review
- Interobserver Reliability of the Endoscopic Ultrasound Criteria for the Diagnosis of Early Chronic Pancreatitis: Comparison between the 2009 and 2019 Japanese Diagnostic Criteria.Diagnostics (Basel, Switzerland) · 2021Article
- The unique pancreatic stellate cell gene expression signatures are associated with the progression from acute to chronic pancreatitis.Computational and structural biotechnology journal · 2021Article
- Endosonographic features in patients with non-alcoholic early chronic pancreatitis improved with treatment at one year follow up.Journal of clinical biochemistry and nutrition · 2021Article
- Endoscopic Ultrasonography Findings of Early and Suspected Early Chronic Pancreatitis.Diagnostics (Basel, Switzerland) · 2020Review
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Authors and funding
30 authors.
Funding
Abstract
backgroundChronic pancreatitis (CP) is a fibro-inflammatory disease of the pancreas. Early diagnosis and intervention, before CP becomes established and irreversible, are essential to improve the long-term outcomes. The world's first diagnostic criteria for early CP were proposed in Japan in 2009, but their clinical utility remains elusive. This study aimed to clarify whether patients with early CP progress to definite CP.
methodsThis is a multicenter, prospective study. Patients diagnosed as having early CP according to the Japanese diagnostic criteria were prospectively followed for 2 years. Clinical profiles including symptoms, drinking and smoking status, laboratory data, imaging findings and treatments were analyzed.
resultsAmong the 83 patients who completed the 2-year follow-up period, four (4.8%) patients progressed to definite CP. The diagnosis of 48 (57.8%) patients was unchanged, and that of 31 (37.3%) patients was downgraded. All the four progressive patients were male, alcohol-related, smokers (3 current and 1 ever), and continued drinking. Comparison of the clinical profiles between the progression group (n = 4) and non-progression group (n = 79) revealed that etiology (alcohol-related), smoking status and presence of acute pancreatitis episodes were associated with the progression to definite CP.
conclusionsThe Japanese diagnostic criteria could identify some patients before the progression to definite CP, while the majority of the patients did not progress. TRIAL REGISTRATION NUMBER: UMIN000015992.
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