SynthesisJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2019
Irreversible electroporation for catheter-based cardiac ablation: a systematic review of the preclinical experience.
Synthesis in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect and Safety of Pulsed Field Ablation (PFA) in Patients With Paroxysmal Atrial Fibrillation (PAF)-A Prospective Multicenter Single-arm Study
Safety and Effectiveness Evaluation of the THERMOCOOL SMARTTOUCH SF Catheter With the TRUPULSE Generator for Treatment of Drug Refractory Symptomatic Paroxysmal Atrial Fibrillation (PAF)
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pulsed field ablation versus thermal energy ablation for atrial fibrillation: a systematic review and meta-analysis of procedural efficiency, safety, and efficacy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Pooled it
- Evaluation of variable inter-pulse delay and timing on pulsed field ablation lesion characteristics.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Computational Assessment of Electrical and Thermal Effects of Epicardial Pulsed Field Ablation Adjacent to Stented Arteries.Bioengineering (Basel, Switzerland) · 2026Article
- Minimization of Cancellation Effect with Nisin During Bipolar Nanosecond Electrochemotherapy.International journal of molecular sciences · 2026Article
- Evolving modalities of atrial fibrillation ablation: From thermal to nonthermal.Heart rhythm O2 · 2026Article
- Fundamentals of System Design for Cardiac Pulsed Field Ablation: Optimization of Safety, Efficacy, and Usability.Pacing and clinical electrophysiology : PACE · 2026Review
- Lesion Formation in Cardiac Pulsed-Field Ablation: Acute to Chronic Cellular Level Changes.Pacing and clinical electrophysiology : PACE · 2026Review
- Efficacy of Peak Frequency in Pulmonary Vein Isolation Using Pulsed Field Ablation for Atrial Fibrillation.Journal of cardiovascular electrophysiology · 2025Article
- Minimizing Atrioesophageal Fistula Risk After AF Ablation: Risk Factors, Prevention, and Emerging Mini-Thermal Technology.Pacing and clinical electrophysiology : PACE · 2025Review
- High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds.Journal of visualized experiments : JoVE · 2025Article
- Asmeton minimizes dry cough and diaphragmatic contraction during pulsed-field ablation of atrial fibrillation: a clinical prospective randomized study.Frontiers in physiology · 2025Article
- The importance of electrode-tissue proximity in creating pulsed field ablation lesions: insights from a sub-acute preclinical model.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- A New Hope for the Treatment of Atrial Fibrillation: Application of Pulsed-Field Ablation Technology.Journal of cardiovascular development and disease · 2024Review
- Use of pulse field ablation in the treatment of an atrial tachycardia: A case report.Clinical case reports · 2024Article
- Pulsed-field ablation versus thermal ablation for atrial fibrillation: A meta-analysis.Heart rhythm O2 · 2024Review
- Pulsed Field Energy in Atrial Fibrillation Ablation: From Physical Principles to Clinical Applications.Journal of clinical medicine · 2024Review
- Pulsed Field Ablation for Atrial Fibrillation: Mechanisms, Advantages, and Limitations.Reviews in cardiovascular medicine · 2024Review
- Dynamics of cell membrane lesions and adaptive conductance under the electrical stress.Cell stress · 2024Article
- Pulsed electric field performance calculator tool based on anFrontiers in physiology · 2024Article
- Respiratory control minimizes diaphragmatic contraction and dry cough during pulsed-field ablation of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIrreversible electroporation (IRE) utilizing high voltage pulses is an emerging strategy for catheter-based cardiac ablation with considerable growth in the preclinical arena.
methodsA systematic search for articles was performed from three sources (PubMed, EMBASE, and Google Scholar). The primary outcome was the efficacy of tissue ablation with characteristics of lesion formation evaluated by histologic analysis. The secondary outcome was focused on safety and damage to collateral structures.
resultsSixteen studies met inclusion criteria. IRE was most commonly applied to the ventricular myocardium (n = 7/16, 44%) by a LifePak 9 Defibrillator (n = 9/16, 56%), NanoKnife Generator (n = 2/16, 13%), or other custom generators (n = 5/16, 31%). There was significant heterogeneity regarding electroporation protocols. On histological analysis, IRE was successful in creating ablation lesions with variable transmurality depending on the electric pulse parameters and catheter used.
conclusionPreclinical studies suggest that cardiac tissue ablation using IRE shows promise in delivering efficacious, safe lesions.
Indexed as
Identifiers
31270656What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.