ReviewOdontology2020
Estrogen signaling impacts temporomandibular joint and periodontal disease pathology.
Review in Odontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06329596 (Periodontal Disease and Alterations in the Oral and Vaginal Microbiome Communities Among Gravidae Chewing Xylitol-gum in Malawi), which is not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Periodontal Disease and Alterations in the Oral and Vaginal Microbiome Communities Among Gravidae Chewing Xylitol-gum in Malawi: Microbiome Alterations With Xylitol (MAX) in Pregnancy Trial.
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Extracorporeal shock wave therapy for temporomandibular disorders: efficacy on pain, maximal mouth opening, and dysfunction-a meta-analysis of randomized controlled trials.Frontiers in rehabilitation sciences · 2026Pooled it
- Temporomandibular disorder prevalence in malocclusion patients: a meta-analysis.Head & face medicine · 2025Pooled it
- Association between Estrogen Levels and Temporomandibular Disorders: An Updated Systematic Review.International journal of molecular sciences · 2024Pooled it
- Temporomandibular Disorders Diagnosis: Current Challenges and the Promising Role of Artificial Intelligence.European journal of dentistry · 2026Article
- Four-Dimensional Impact of Oral Behaviours on Oral Health-Related Quality of Life Across TMD Subtypes: A Parallel Multivariate Exploration.Journal of oral rehabilitation · 2026Article
- Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management.Neuroscience bulletin · 2026Review
- Sex-Specific Oral Health: A Narrative Review of Hormonal Influences and Disease Patterns.Dentistry journal · 2026Review
- Sex, Gender and Sexuality in Oral Health Research: Setting the Scene.Advances in dental research · 2026Article
- Bone Metabolic Changes and Osteoporosis During Pregnancy and Lactation: A View from Dental Medicine.International journal of molecular sciences · 2025Review
- Exploring the Therapeutic Potential of Epigallocatechin-3-gallate (Green Tea) in Periodontitis Using Network Pharmacology and Molecular Modeling Approach.International journal of molecular sciences · 2025Article
- Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Review
- Oral Health and Sociodemographic Aspects in Transgender People: A Descriptive Exploratory Study.Journal of oral rehabilitation · 2025Article
- Involvement of the gene encoding the collagen type II alpha 1 chain in mandibular mobility.BMC oral health · 2025Article
- Clinical, psychological, and hematological factors predicting sleep bruxism in patients with temporomandibular disorders.Scientific reports · 2025Observational
- Oral Manifestations in Menopause-A Scoping Review.Medicina (Kaunas, Lithuania) · 2025Article
- Causal Relationship Between Autoimmune Arthritis and Temporomandibular Disorders.International dental journal · 2025Article
- Sex differences in the orofacial antinociceptive effect of metformin and the role of transient receptor potential channels.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Link between caries, periodontitis, and pregnancy: The role of personalized oral hygiene.World journal of clinical cases · 2025Article
- The impact of estrogen on periodontal tissue integrity and inflammation-a mini review.Frontiers in dental medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Women experience a higher incidence of oral diseases including periodontal diseases and temporomandibular joint disease (TMD) implicating the role of estrogen signaling in disease pathology. Fluctuating levels of estrogen during childbearing age potentiates facial pain, high estrogen levels during pregnancy promote gingivitis, and low levels of estrogen during menopause predisposes the TMJ to degeneration and increases alveolar bone loss. In this review, an overview of estrogen signaling pathways in vitro and in vivo that regulate pregnancy-related gingivitis, TMJ homeostasis, and alveolar bone remodeling is provided. Deciphering the specific estrogen signaling pathways for individual oral diseases is crucial for potential new drug therapies to promote and maintain healthy tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.