Evidence map›Paper›PMID 31270583›Full record

ArticleDiabetologia2019

Circulating CXCR5

Ilse Ekman, Emmi-Leena Ihantola, Tyyne Viisanen, Deepak A Rao, Kirsti Näntö-Salonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Tuure Kinnunen

Open access · hybridAbstract read
In one paragraph

Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 104 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  8. Article
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  11. 3-in-oneiScience · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Predictive value of circulating PD-1Frontiers in medicine · 2025
    Article
  18. Article
  19. Article
  20. Occurrence and role of Tph cells in various renal diseases.Molecular medicine (Cambridge, Mass.) · 2024
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Ilse EkmanDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1 C, FIN-70210, Kuopio, Finland.
Emmi-Leena IhantolaDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1 C, FIN-70210, Kuopio, Finland.
Tyyne ViisanenDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1 C, FIN-70210, Kuopio, Finland.
Deepak A RaoDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kirsti Näntö-SalonenDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Mikael KnipTampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland.
Riitta VeijolaDepartment of Pediatrics, Medical Research Center, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, Oulu, Finland.
Jorma ToppariDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Jorma IlonenImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.
Tuure KinnunenDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1 C, FIN-70210, Kuopio, Finland. tuure.kinnunen@uef.fi.ORCID 0000-0003-1595-5371
University of Eastern Finland · FIUniversity of Turku · FIBrigham and Women's Hospital · USOulu University Hospital · FITurku University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisType 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive (CXCR5

methodsThe phenotype of blood CXCR5

resultsCirculating CXCR5 CONCLUSIONS/

interpretationOur results demonstrate that circulating CXCR5

Indexed as

BiomarkersCD4-Positive T-LymphocytesChildChild, PreschoolCoculture TechniquesDiabetes Mellitus, Type 1FemaleHumansMaleProgrammed Cell Death 1 ReceptorReceptors, CXCR5T-LymphocytesBiomarkersCXCR5 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, CXCR5AutoimmunityB cellsFollicular T helper cellHumanImmunophenotypingPeripheral T helper cellT cellsType 1 diabetes

Identifiers

PMID31270583
PMCPMC6677711
OpenAlexW2955620942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.