ArticleNature2019
Somatic mutations and cell identity linked by Genotyping of Transcriptomes.
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In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
What it found
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Who cites it
217 citing papers in PubMed, 1 synthesis or guideline pooled it, 323 citations in OpenAlex.
- Clonal hematopoiesis is associated with protection from Alzheimer's disease.Nature medicine · 2023Pooled it
- Computational approaches for multimodal lineage tracing.Nature reviews. Genetics · 2026Review
- Type 1 interferon perturbates clonal competition by reshaping human blood development.Nature genetics · 2026Article
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- Putting the I in AML: Artificial Intelligence and Machine Learning in Acute Myeloid Leukemia.Cells · 2026Review
- Minimal Residual Disease as a Biological Trait: Rethinking Disease Persistence in Hematologic Malignancies.European journal of haematology · 2026Review
- Single-cell long-read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML.Blood advances · 2026Article
- Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.Nature biotechnology · 2026Article
- Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencing.bioRxiv : the preprint server for biology · 2026Article
- Integrating Single-Cell Sequencing and Proteomics to Unravel Stem Cell Heterogeneity: Implications for Precision Regenerative Medicine.Stem cell reviews and reports · 2026Review
- Lineage tracing from cellular heritage to disease destiny.Nature genetics · 2026Review
- Immunogenetic and Transcriptomic Evidence Implicating the NKG2D-MICA/MICB Axis in CALR-Mutated Myeloproliferative Neoplasms.Cancers · 2026Article
- Article
- circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics.Genome medicine · 2026Article
- Charting single-cell lineages with synthetic and natural barcodes.Nature reviews. Genetics · 2026Review
- Distinct stem cell identities converge into shared erythroid stress in ERCC6L2 disease and Shwachman-Diamond syndrome.HemaSphere · 2026Article
- Inhibition of ADSS2-mediated de novo AMP biosynthesis re-sensitizes acute myeloid leukemia to BH3 mimetics.Nature cancer · 2026Article
- Hybrid untargeted short-read and targeted long-read RNA sequencing facilitates genotype-phenotype associations at single-cell resolution.Genome biology · 2026Article
- Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts.Cancer discovery · 2026Article
- Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing.Nature communications · 2026Article
157 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 7 institutions in 1 country.
Anna S Nam *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Kyu-Tae Kim *New York Genome Center, New York, NY, USA.
Ronan Chaligne *New York Genome Center, New York, NY, USA.
Franco IzzoNew York Genome Center, New York, NY, USA.
Chelston AngNew York Genome Center, New York, NY, USA.
Justin TaylorHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Robert M MyersNew York Genome Center, New York, NY, USA.
Ghaith Abu-ZeinahDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Ryan BrandNew York Genome Center, New York, NY, USA.
Nathaniel D OmansNew York Genome Center, New York, NY, USA.
Alicia AlonsoEpigenomics Core Facility, Weill Cornell Medicine, New York, NY, USA.
Caroline SheridanEpigenomics Core Facility, Weill Cornell Medicine, New York, NY, USA.
Marisa MarianiEpigenomics Core Facility, Weill Cornell Medicine, New York, NY, USA.
Xiaoguang DaiOxford Nanopore Technologies, New York, NY, USA.
Eoghan HarringtonOxford Nanopore Technologies, New York, NY, USA.
Alessandro PastoreHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Juan R Cubillos-RuizDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Wayne TamDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Ronald HoffmanDivision of Hematology and Medical Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Raul RabadanDepartment of Systems Biology, Columbia University Medical Center, New York, NY, USA.
Joseph M ScanduraSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Omar Abdel-WahabHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Peter SmibertTechnology Innovation Lab, New York Genome Center, New York, NY, USA.
Dan A LandauNew York Genome Center, New York, NY, USA. dlandau@nygenome.org.
Cornell University · USWeill Cornell Medicine · USMemorial Sloan Kettering Cancer Center · USNew York Genome Center · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USRockefeller University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MDisparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2MTissue BankP01CA108671 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Ronald Hoffman · 2006 to 2026
$82.0MTopology of Cancer Evolution and HeterogeneityU54CA193313 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2015 to 2020
$10.4MTARGETING RETROVIRAL VECTORS TO HEMATOPOIETIC STEM CELLSP01HL053762 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI KAN, YUET W · 1994 to 2004
$5.1MShapeshifters in Cancer: Defining the Fundamental Forces of Leukemia EvolutionDP2CA239065 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN · 2018 to 2018
$2.5MDefining Epidrivers of CLL Evolution in Response to Targeted TherapyR01CA229902 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN · 2018 to 2022
$2.4MThe role of DNA methylation modifiers in shaping the hematopoietic differentiation topologyR01HL145283 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN · 2019 to 2022
$2.0MNCATS NIH HHS UL1 TR002384NCI NIH HHS DP2 CA239065NCI NIH HHS P01 CA108671NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA229902NCI NIH HHS U54 CA193313NHLBI NIH HHS P01 HL053762NHLBI NIH HHS R01 HL145283
Abstract
Defining the transcriptomic identity of malignant cells is challenging in the absence of surface markers that distinguish cancer clones from one another, or from admixed non-neoplastic cells. To address this challenge, here we developed Genotyping of Transcriptomes (GoT), a method to integrate genotyping with high-throughput droplet-based single-cell RNA sequencing. We apply GoT to profile 38,290 CD34
Indexed as
GenotypeMutationAnimalsAntigens, CD34CalreticulinCell LineCell ProliferationClone CellsEndoribonucleasesHematopoiesisHematopoietic Stem CellsHigh-Throughput Nucleotide SequencingHumansMiceModels, MolecularMyeloproliferative DisordersAntigens, CD34CalreticulinCALR protein, humanEndoribonucleasesERN1 protein, humanNF-kappa BProtein Serine-Threonine Kinases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.