Evidence map›Paper›PMID 31270452›Full record

ArticleNature nanotechnology2019

On the issue of transparency and reproducibility in nanomedicine.

Hon S Leong, Kimberly S Butler, C Jeffrey Brinker, May Azzawi, Steve Conlan, Christine Dufés, Andrew Owen, Steve Rannard, Chris Scott, Chunying Chen and 68 more

Erratum issuedAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.Drug delivery and translational research · 2026
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

78 authors.

Hon S LeongDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Kimberly S ButlerDepartment of Nanobiology, Sandia National Laboratories, Albuquerque, NM, USA.
C Jeffrey BrinkerCenter for Micro-Engineered Materials, University of New Mexico Albuquerque, Albuquerque, NM, USA.
May AzzawiCardiovascular Research Group, School of Healthcare Science, Manchester Metropolitan University, Manchester, UK.
Steve ConlanBritish Society for Nanomedicine.
Christine DufésBritish Society for Nanomedicine.
Andrew OwenBritish Society for Nanomedicine.
Steve RannardBritish Society for Nanomedicine.
Chris ScottBritish Society for Nanomedicine.
Chunying ChenNational Center for Nanoscience and Technology of China, Beijing, China.
Marina A DobrovolskaiaCancer Research Technology Program, Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Serguei V KozlovLaboratory of Animal Sciences Program, Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Adriele Prina-MelloTrinity Translational Medicine Institute, Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.
Ruth SchmidSINTEF Industry, Trondheim, Norway.
Peter WickEmpa - Swiss Federal Laboratories for Materials Science and Technology, St Gallen, Switzerland.
Fanny CaputoUniversity Grenoble Alpes, CEA, LETI, Grenoble, Switzerland.
Patrick BoisseauUniversity Grenoble Alpes, CEA, LETI, Grenoble, Switzerland.
Rachael M CristCancer Research Technology Program, Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Scott E McNeilCancer Research Technology Program, Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Bengt FadeelInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Lang TranInstitute of Occupational Medicine, Edinburgh, UK.
Steffen Foss HansenDepartment of Environmental Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
Nanna B HartmannDepartment of Environmental Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
Lauge P W ClausenDepartment of Environmental Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
Lars M SkjoldingDepartment of Environmental Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
Anders BaunDepartment of Environmental Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
Marlene ÅgerstrandDepartment of Environmental Science and Analytical Chemistry (ACES), Stockholm University, Stockholm, Sweden.
Zhen GuDepartment of Bioengineering, California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Dimitrios A LamprouSchool of Pharmacy, Queen's University Belfast, Belfast, UK.
Clare HoskinsInstitute of Science and Technology in Medicine, Keele University, Keele, UK.
Leaf HuangDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Wantong SongKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Huiliang CaoState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
Xuanyong LiuState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
Klaus D JandtOtto Schott Institute of Materials Research, Friedrich Schiller University Jena, Jena, Germany.
Wen JiangDepartment of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Betty Y S KimDepartment of Neurosurgery, The University of Texas MD Anderson Cancer, Houston, TX, USA.
Korin E WheelerDepartment of Chemistry and Biochemistry, Santa Clara University, Santa Clara, CA, USA.
Andrew J ChetwyndSchool of Geography Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
Iseult LynchSchool of Geography Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
Seyed Moein MoghimiSchool of Pharmacy, Newcastle University, Newcastle upon Tyne, UK.
André NelDivision of NanoMedicine, Department of Medicine, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Tian XiaDivision of NanoMedicine, Department of Medicine, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Paul S WeissDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Bruno Sarmentoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
José das Nevesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Hélder A SantosFaculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Luis SantosDosage Form Design and Development, MedImmune, LLC, Gaithersburg, MD, USA.
Samir MitragotriWyss Institute of Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
Steve LittleDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Dan PeerGeorge S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Mansoor M AmijiSchool of Pharmacy, Northeastern University, Boston, MA, USA.
Maria José AlonsoCIMUS Research Institute, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Alke Petri-FinkAdolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Sandor BalogAdolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Aaron LeeAdolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Barbara DraslerAdolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Barbara Rothen-RutishauserDepartment of Chemistry, University of Fribourg, Fribourg, Switzerland.
Stefan WilhelmStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.
Handan AcarStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.
Roger G HarrisonStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.
Chuanbin MaoStephenson Cancer Center, Oklahoma City, OK, USA.
Priyabrata MukherjeeStephenson Cancer Center, Oklahoma City, OK, USA.
Rajagopal RameshStephenson Cancer Center, Oklahoma City, OK, USA.
Lacey R McNallyDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sara BusattoDepartment of Transplantation Medicine, Mayo Clinic, Jacksonville, FL, USA.
Joy WolframDepartment of Transplantation Medicine, Mayo Clinic, Jacksonville, FL, USA.
Paolo BergeseDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Mauro FerrariDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
Ronnie H FangDepartment of NanoEngineering, Chemical Engineering Program, University of California, San Diego, La Jolla, CA, USA.
Liangfang ZhangMoores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
Jie ZhengDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
Chuanqi PengDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
Bujie DuDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
Mengxiao YuDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
Danielle M CharronInstitute of Biomaterials and Biomedical Engineering, University of Toronto Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Gang ZhengDepartment of Medical Biophysics, University of Toronto Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Chiara PastoreNature Nanotechnology, London, UK. Chiara.Pastore@nature.com.

Funding

Molecular Mechanism of Antiangiogenic Properties of Gold NanoparticleR01CA136494 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MUKHERJEE, PRIYABRATA · 2009 to 2020
$2.9M
Stroma Targeted Theranostic Nanoparticles for Pancreatic CancerR01CA212350 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2017 to 2021
$1.7M
Reprogramming Tumor Microenvironment by NanoparticleR01CA213278 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MUKHERJEE, PRIYABRATA · 2017 to 2021
$1.7M
Theranostic Nanoparticles For Detection and Treatment of Pancreatic CancerR01EB020125 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2019
$1.7M
Cancer Research UK 21094CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS R01 CA136494NCI NIH HHS R01 CA212350NCI NIH HHS R01 CA213278NIBIB NIH HHS R01 EB020125
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NanomedicineAnimalsEditorial PoliciesHumansPeriodicals as TopicReproducibility of ResultsResearch

Identifiers

PMID31270452
PMCPMC6939883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.