ArticleNature communications2019
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 2 of them syntheses that pooled it.
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116citing papers in PubMed, 2 pooled it
10.6field-weighted citation impact, top 1% of its field
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Who cites it
116 citing papers in PubMed, 2 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Metabolomics in Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2022Pooled it
- Iron Deficiency Is Associated With Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Pooled it
- Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women.Malaria journal · 2022Trial
- Ferric carboxymaltose and SARS-CoV-2 vaccination-induced immunogenicity in kidney transplant recipients with iron deficiency: The COVAC-EFFECT randomized controlled trial.Frontiers in immunology · 2022Trial
- Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants.Frontiers in immunology · 2020Trial
- Intracellular growth ofeLife · 2026Article
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- Exploring the Immunohistochemical Expression of Iron-Related Proteins in Non-Metastatic and Metastatic Feline Mammary Carcinomas.Veterinary sciences · 2026Article
- Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia.Nature communications · 2026Article
- Proximity labeling at H3K9me3 reveals VRK-1 regulate global chromatin distribution inbioRxiv : the preprint server for biology · 2026Article
- The role of metal ions iron, copper, and zinc in the immune microenvironment of gastric cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- The crosstalk between iron metabolism and immune tolerance in autoimmunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Heme enhances B-cell proliferation and plasma cell formation through reduced p21 and Rb expression.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.ACS nano · 2026Article
- Dietary iron deficiency impairs effector function of memory T cells following influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Immunoglobulin heavy-chain status and stromal interactions shape ferroptosis sensitivity in chronic lymphocytic leukemia.Signal transduction and targeted therapy · 2026Article
- KDM3B Predicts Expression Signature, Prognosis Value, and Immune Characteristics of Cancers: A Pan-Cancer Analysis.BioMed research international · 2026Article
- Effects of essential metals (iron, zinc, and copper) on thyroid diseases - a narrative review.Frontiers in medicine · 2026Review
- Association of plasma ferritin and plasma iron at time of vaccination with the immune response to SARS-CoV-2 vaccination: a longitudinal cohort study.Frontiers in immunology · 2026Article
- Iron as an immunometabolic signal in infection and inflammation.Frontiers in immunology · 2026Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 6 institutions in 1 country.
Yuhang JiangAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China.ORCID http://orcid.org/0000-0002-6396-2309
Cuifeng LiAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China.
Qian WuThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, 310058, Hangzhou, China.ORCID http://orcid.org/0000-0003-3934-0128
Peng AnThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Laiquan HuangDepartment of Hematology, The First Affiliated Hospital of Wannan Medical College, 241000, Wuhu, China.ORCID http://orcid.org/0000-0002-7139-9755
Jia WangThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Chen ChenDepartment of Hematology, Zhongshan Hospital Fudan University, 200032, Shanghai, China.
Xi ChenAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China.
Fan ZhangThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Li MaKey Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Sanhong LiuCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Hanqing HeZhejiang Provincial Center for Disease Control and Prevention, 310051, Hangzhou, China.
Shuyun XieZhejiang Provincial Center for Disease Control and Prevention, 310051, Hangzhou, China.
Yangbai SunZhejiang Provincial Center for Disease Control and Prevention, 310051, Hangzhou, China.
Hanshao LiuAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China.
Yu ZhanCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Yu TaoCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Zhi LiuAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China.
Xiaohua SunAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China.
Yiming HuAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China.
Qi WangCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Deji YeCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Jie ZhangCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Shanhua ZouDepartment of Hematology, Zhongshan Hospital Fudan University, 200032, Shanghai, China.
Ying WangCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Gang WeiKey Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Yongzhong LiuShanghai Cancer Institute, Shanghai Jiao-Tong University School of Medicine, 200240, Shanghai, China.ORCID http://orcid.org/0000-0002-1477-116X
Yufang ShiCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.ORCID http://orcid.org/0000-0001-9716-2126
Y Eugene ChinCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
Yongqiang HaoShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 200011, Shanghai, China.
Fudi WangThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, 310058, Hangzhou, China. fwang@zju.edu.cn.ORCID http://orcid.org/0000-0001-8730-0003
Xiaoren ZhangAffiliated Cancer Hospital & Institute, Guangzhou Medical University, 510000, Guangzhou, China. xrzhang@sibs.ac.cn.
Shanghai Institute of Nutrition and Health · CNZhengzhou University · CNZhejiang Center for Disease Control and Prevention · CNShanghai Jiao Tong University · CNSun Yat-sen University · CNFirst Affiliated Hospital of Wannan Medical College · CN
Funding
National Natural Science Foundation of China (National Science Foundation of China) 31370881National Natural Science Foundation of China (National Science Foundation of China) 31530034National Natural Science Foundation of China (National Science Foundation of China) 31570902
Abstract
Trace elements play important roles in human health, but little is known about their functions in humoral immunity. Here, we show an important role for iron in inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the measles vaccine when compared to iron-normal controls. Mice with iron deficiency also exhibit attenuated T-dependent or T-independent antigen-specific antibody responses. We show that iron is essential for B cell proliferation; both iron deficiency and α-ketoglutarate inhibition could suppress cyclin E1 induction and S phase entry of B cells upon activation. Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation. Thus, our data reveal a crucial role of H3K9 demethylation in B cell proliferation, and the importance of iron in humoral immunity.
Indexed as
Cell ProliferationImmunity, HumoralAnimalsB-LymphocytesCell CycleCells, CulturedCyclin EDemethylationF-Box ProteinsHistonesIronJumonji Domain-Containing Histone DemethylasesLymphocyte ActivationLysineMiceMice, Inbred C57BLCyclin Ecyclin E1, mouseF-Box ProteinsHistonesIronJmjd2c protein, mouseJumonji Domain-Containing Histone DemethylasesKdm2b protein, mouseKdm3b protein, mouseLysineOncogene Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.