ArticleNature communications2019
Neuroepigenetic signatures of age and sex in the living human brain.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration.Frontiers in aging neuroscience · 2021Pooled it
- Simvastatin rescues cognitive impairment in an AβNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Gut microbiota as a modulator of HDAC: insights into Alzheimer's disease treatment.Pharmacological reports : PR · 2026Review
- Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026Review
- Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease.Clinical epigenetics · 2026Article
- Towards a personalized perspective on gliomas: an epigenetic-immuno-inflammatory aging framework.Frontiers in immunology · 2026Review
- Multi-omics protein signaling networks identify sex-specific therapeutic candidates in lung adenocarcinoma.Biology of sex differences · 2025Article
- Tangible advantages of multi-stage brain motion compensation for PET imaging demonstrated in multiple studies.medRxiv : the preprint server for health sciences · 2025Article
- CoREST3 exhibits isoform specific expression in Alzheimer's disease and regulation of HDAC2.BMC biology · 2025Article
- Identifying Sex Differences in Lung Adenocarcinoma Using Multi-Omics Integrative Protein Signaling Networks.bioRxiv : the preprint server for biology · 2025Article
- PET-MRI Applications and Future Prospects in Psychiatry.Journal of magnetic resonance imaging : JMRI · 2025Review
- Article
- Review
- The impact of sex on memory during aging and Alzheimer's disease progression: Epigenetic mechanisms.Journal of Alzheimer's disease : JAD · 2024Review
- Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study.iScience · 2024Article
- Epigenetics of Fear, Anxiety and Stress - Focus on Histone Modifications.Current neuropharmacology · 2024Article
- Sex-specific epigenetic programming in renal fibrosis and inflammation.American journal of physiology. Renal physiology · 2023Review
- Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging.Brain sciences · 2023Review
- Epigenetic MRI: Noninvasive imaging of DNA methylation in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 2 institutions in 1 country.
Tonya M GilbertAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Nicole R ZürcherAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0003-0271-6304
Mary C CataneseAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Chieh-En J TsengAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0003-0592-335X
Maria A Di BiasePsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
Amanda E LyallPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0001-8049-516X
Baileigh G HightowerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Anjali J ParmarAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Anisha BhanotAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Christine J WuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0002-2464-9205
Matthew L HibertAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Minhae KimAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0003-3148-1540
Umar MahmoodAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Steven M StufflebeamAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0002-7011-5212
Frederick A SchroederAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Changning WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Joshua L RoffmanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Daphne J HoltAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Douglas N GreveAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
Marek KubickiPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
Hsiao-Ying WeyAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Jacob M HookerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA. hooker@nmr.mgh.harvard.edu.
Harvard University · USBrigham and Women's Hospital · US
Funding
Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9MProject 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8MDiffusion Imaging Biomarkers for Risk, Onset and Outcome in SchizophreniaR01MH102377 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2014 to 2018
$2.8MDesign of Class-specific HDAC Imaging Probes for Positron Emission TomographyR01DA030321 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2010 to 2014
$2.4MNext Generation Diffusion MRI Biomarkers for Prodromal SchizophreniaR01MH108574 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI PASTERNAK, OFER · 2016 to 2020
$2.2MCombined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataS10RR022976 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE · 2007 to 2007
$2.0MA Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0MSILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5MMentoring and Neuroimaging Research on White Matter Pathology in SchizophreniaK24MH110807 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2017 to 2021
$945kAssessing Dynamic Opioid-Dopamine Interactions Using Simultaneous PET/MRIR00DA037928 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI WEY, HSIAO-YING · 2016 to 2018
$747kCarbon-11 Automation Equipment for Human PET Radiotracer ProductionS10OD023517 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2018 to 2018
$502kCYCLOTRON &RADIOCHEMISTRY: SUBSTANCE ABUSE, COCAINE, OPIOIDS10RR017208 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2004
$500kNCRR NIH HHS S10 RR017208NCRR NIH HHS S10 RR019933NCRR NIH HHS S10 RR022976NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NCRR NIH HHS S10 RR026666NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41 EB015902NIDA NIH HHS R00 DA037928NIDA NIH HHS R01 DA030321NIH HHS S10 OD023517NIMH NIH HHS K24 MH110807NIMH NIH HHS R01 MH102377NIMH NIH HHS R01 MH108574NIMH NIH HHS R03 MH110745NIMH NIH HHS R21 MH111971U.S. Department of Energy (DOE) DE-SC0008430U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) P41EB015896U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) P41EB015902U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K24MH110807U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH102377U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH108574U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R03MH110745U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH11197101A1U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R00DA037928
Abstract
Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate gene transcription in the brain. Here, we measure in vivo expression of the epigenetic enzymes, histone deacetylases (HDACs), across healthy human aging and between sexes using [
Indexed as
Epigenesis, GeneticSex CharacteristicsAdamantaneAdolescentAdultAgedAge FactorsBrainCarbon RadioisotopesEmotionsFemaleHistone Deacetylase 1Histone Deacetylase 2HumansHydroxamic AcidsMaleAdamantaneCarbon-11Carbon RadioisotopesHistone Deacetylase 1Histone Deacetylase 2Hydroxamic Acidsmartinostat
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.