Evidence map›Paper›PMID 31270330›Full record

ArticleNature communications2019

DNA assembly for nanopore data storage readout.

Randolph Lopez, Yuan-Jyue Chen, Siena Dumas Ang, Sergey Yekhanin, Konstantin Makarychev, Miklos Z Racz, Georg Seelig, Karin Strauss, Luis Ceze

Abstract readEvaluation Study
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Primer-Disk-Enabled DNA Data Storage System with Index and Record-Many-Read-Many Features.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Article
  12. DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. A primordial DNA store and compute engine.Nature nanotechnology · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Randolph LopezDepartment of Bioengineering, University of Washington, Seattle, WA, 98105, USA.
Yuan-Jyue ChenMicrosoft Research, Redmond, WA, 98052, USA.
Siena Dumas AngMicrosoft Research, Redmond, WA, 98052, USA.
Sergey YekhaninMicrosoft Research, Redmond, WA, 98052, USA.
Konstantin MakarychevMicrosoft Research, Redmond, WA, 98052, USA.
Miklos Z RaczMicrosoft Research, Redmond, WA, 98052, USA.
Georg SeeligMolecular Engineering & Sciences Institute, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-3163-8782
Karin StraussMicrosoft Research, Redmond, WA, 98052, USA.
Luis CezePaul G. Allen School for Computer Science & Engineering, University of Washington, Seattle, WA, 98195, USA. luisceze@cs.washington.edu.ORCID http://orcid.org/0000-0002-1377-6217

Funding

United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) Molecular Informatics
6 · The paper itself

Abstract

Synthetic DNA is becoming an attractive substrate for digital data storage due to its density, durability, and relevance in biological research. A major challenge in making DNA data storage a reality is that reading DNA back into data using sequencing by synthesis remains a laborious, slow and expensive process. Here, we demonstrate successful decoding of 1.67 megabytes of information stored in short fragments of synthetic DNA using a portable nanopore sequencing platform. We design and validate an assembly strategy for DNA storage that drastically increases the throughput of nanopore sequencing. Importantly, this assembly strategy is generalizable to any application that requires nanopore sequencing of small DNA amplicons.

Indexed as

Databases, GeneticDNAInformation Storage and RetrievalNanoporesNanotechnologySequence Analysis, DNADNA

Identifiers

PMID31270330
PMCPMC6610119

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.