Evidence map›Paper›PMID 31270239›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Deep evolutionary origin of limb and fin regeneration.

Sylvain Darnet, Aline C Dragalzew, Danielson B Amaral, Josane F Sousa, Andrew W Thompson, Amanda N Cass, Jamily Lorena, Eder S Pires, Carinne M Costa, Marcos P Sousa and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 76 citations in OpenAlex.

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  9. The In Vitro Enhancement of Retinal Cell Viability via mInternational journal of molecular sciences · 2024
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  14. Suppressors of cGAS-STING are downregulated during fin-limb regeneration and aging in aquatic vertebrates.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024
    Article
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  16. Review
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  20. NaPhysiological genomics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Sylvain DarnetInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil.ORCID 0000-0001-6351-0903
Aline C DragalzewInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil.
Danielson B AmaralInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil.
Josane F SousaInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil.
Andrew W ThompsonDepartment of Integrative Biology, Program in Ecology, Evolutionary Biology, and Behavior, Michigan State University, East Lansing, MI 48824.
Amanda N CassDepartment of Biology, James Madison University, Harrisonburg, VA 22807.
Jamily LorenaInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil.
Eder S PiresInstituto Tecnológico Vale, 66055-090 Belém, Brazil.
Carinne M CostaInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil.
Marcos P SousaLaboratório de Biologia Molecular, Museu Paraense Emílio Goeldi, 66077-530 Belém, Pará, Brazil.
Nadia B FröbischMuseum für Naturkunde, Leibniz Institute for Evolution and Biodiversity Science, 10115 Berlin, Germany.
Guilherme OliveiraInstituto Tecnológico Vale, 66055-090 Belém, Brazil.ORCID 0000-0003-0054-3438
Patricia N SchneiderInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil.
Marcus C DavisDepartment of Biology, James Madison University, Harrisonburg, VA 22807.
Ingo BraaschDepartment of Integrative Biology, Program in Ecology, Evolutionary Biology, and Behavior, Michigan State University, East Lansing, MI 48824.
Igor SchneiderInstituto de Ciências Biológicas, Universidade Federal do Pará, 66075-900 Belém, Brazil; ischneider@ufpa.br.ORCID 0000-0002-9046-7338
Universidade Federal do Pará · BRVale Technological Institute · BRJames Madison University · USMichigan State University · USMuseum für Naturkunde · DEMuseu Paraense Emílio Goeldi · BR

Funding

Resources for Teleost Gene Duplicates and Human DiseaseR01OD011116 · OD · UNIVERSITY OF OREGON · PI POSTLETHWAIT, JOHN H. · 2012 to 2020
$5.4M
Biotechnology and Biological Sciences Research Council BB/P027849/1NIH HHS R01 OD011116
6 · The paper itself

Abstract

Salamanders and lungfishes are the only sarcopterygians (lobe-finned vertebrates) capable of paired appendage regeneration, regardless of the amputation level. Among actinopterygians (ray-finned fishes), regeneration after amputation at the fin endoskeleton has only been demonstrated in polypterid fishes (Cladistia). Whether this ability evolved independently in sarcopterygians and actinopterygians or has a common origin remains unknown. Here we combine fin regeneration assays and comparative RNA-sequencing (RNA-seq) analysis of

Indexed as

Biological EvolutionAmbystoma mexicanumAnimal FinsAnimalsCichlidsCyprinidaeExtremitiesFishesFish ProteinsGene OntologyMolecular Sequence AnnotationPhylogenyRegenerationTranscriptomeFish Proteinsevolutionfinlimbregenerationtetrapod

Identifiers

PMID31270239
PMCPMC6660751
OpenAlexW2953485789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.