Evidence map›Paper›PMID 31270227›Full record

ArticleJournal of virology2019

HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.

Paul Lopez, Wan Hon Koh, Ryan Hnatiuk, Thomas T Murooka

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

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  16. Article
  17. A Holistic Review of the Preclinical Landscape for Long-Acting Anti-infective Drugs Using HIV as a Paradigm.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Review
  18. Article
  19. Article
  20. SARS-CoV-2 and HIV-1: So Different yet so AlikeInternational journal of medical sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paul LopezDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Wan Hon KohDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Ryan HnatiukDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Thomas T MurookaDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada thomas.murooka@umanitoba.ca.ORCID 0000-0002-3030-2726
University of Manitoba · CA

Funding

CIHR HB2-164064
6 · The paper itself

Abstract

Macrophages are susceptible to HIV infection and play an important role in viral dissemination through cell-cell contacts with T cells. However, our current understanding of macrophage-to-T cell HIV transmission is derived from studies that do not consider the robust migration and cell-cell interaction dynamics between these cells. Here, we performed live-cell imaging studies in 3-dimensional (3D) collagen that allowed CD4

Indexed as

CD4 AntigensCD4-Positive T-LymphocytesCell CommunicationHEK293 CellsHIV-1HIV InfectionsHumansIntercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1MacrophagesPrimary Cell CultureVirus ReplicationCD4 AntigensIntercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1cell-cell interactionscell migrationfluorescent reportersHIVlive-cell imagingmacrophagesT cells

Identifiers

PMID31270227
PMCPMC6714792
OpenAlexW2956158086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.