Evidence map›Paper›PMID 31270209›Full record

ArticleThe Journal of biological chemistry2019

Nanoscale dynamics of cholesterol in the cell membrane.

Kerstin Pinkwart, Falk Schneider, Martyna Lukoseviciute, Tatjana Sauka-Spengler, Edward Lyman, Christian Eggeling, Erdinc Sezgin

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 73 citations in OpenAlex.

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  9. Nanoarchitectonics and Simulation on the Molecular-Level Interactions betweenLangmuir : the ACS journal of surfaces and colloids · 2024
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  17. Effects of Dietary Cholesterol Regulation on Spermatogenesis ofInternational journal of molecular sciences · 2023
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Kerstin PinkwartMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.
Falk SchneiderMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.
Martyna LukoseviciuteRadcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.
Tatjana Sauka-SpenglerRadcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.
Edward LymanDepartments of Physics and Astronomy and Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716.
Christian EggelingMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.
Erdinc SezginMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom erdinc.sezgin@rdm.ox.ac.uk.ORCID 0000-0002-4915-388X
University of Oxford · GBLeibniz Institute of Photonic Technology · DEUniversity of Delaware · US

Funding

Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Effects of lipidomic diversity on GPCRR01GM120351 · NIGMS · UNIVERSITY OF DELAWARE · PI LYMAN, EDWARD RAY · 2017 to 2021
$1.6M
Biotechnology and Biological Sciences Research CouncilMedical Research Council G0902418Medical Research Council MC_UU_00008/9Medical Research Council MC_UU_12010/9Medical Research Council MC_UU_12025Medical Research Council MR/K01577X/1NIGMS NIH HHS R01 GM116961NIGMS NIH HHS R01 GM120351Wellcome Trust 104924/14/Z/14Wellcome Trust 215615/Z/19/Z
6 · The paper itself

Abstract

Cholesterol constitutes ∼30-40% of the mammalian plasma membrane, a larger fraction than of any other single component. It is a major player in numerous signaling processes as well as in shaping molecular membrane architecture. However, our knowledge of the dynamics of cholesterol in the plasma membrane is limited, restricting our understanding of the mechanisms regulating its involvement in cell signaling. Here, we applied advanced fluorescence imaging and spectroscopy approaches on

Indexed as

Molecular Dynamics SimulationNanotechnologyAnimalsCell MembraneCells, CulturedCHO CellsCholesterolCricetulusDiffusionFemaleMaleMonte Carlo MethodSpectrometry, FluorescenceZebrafishCholesterolBodipy-cholesterolcholesteroldiffusionfluorescence correlation spectroscopy (FCS)hindered diffusionmembrane asymmetrymembrane biophysicsmembrane lipidmembrane structuremodel membranesplasma membrane

Identifiers

PMID31270209
PMCPMC6709632
OpenAlexW2955111331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.