Evidence map›Paper›PMID 31270160›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice.

Xin Luo, Yul Huh, Sangsu Bang, Qianru He, Linlin Zhang, Megumi Matsuda, Ru-Rong Ji

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 133 citations in OpenAlex.

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  11. Emerging role of macrophages in neuropathic pain.Journal of orthopaedic translation · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Innate immunity in chemotherapy-induced peripheral neuropathy: recent advances.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
  17. Review
  18. Review
  19. Review
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xin LuoCenter for Translational Pain Medicine, Department of Anesthesiology, ru-rong.ji@duke.edu xin.luo@duke.edu.
Yul HuhCenter for Translational Pain Medicine, Department of Anesthesiology.
Sangsu BangCenter for Translational Pain Medicine, Department of Anesthesiology.
Qianru HeCenter for Translational Pain Medicine, Department of Anesthesiology.
Linlin ZhangCenter for Translational Pain Medicine, Department of Anesthesiology.
Megumi MatsudaCenter for Translational Pain Medicine, Department of Anesthesiology.
Ru-Rong JiCenter for Translational Pain Medicine, Department of Anesthesiology, ru-rong.ji@duke.edu xin.luo@duke.edu.
Duke University · USInstitute of Cell Biology · UA

Funding

ORGANIZATION AND FUNCTIONS OF CELLULAR STRUCTUREST32GM007184 · NIGMS · DUKE UNIVERSITY · PI JINKS-ROBERTSON, SUE · 1985 to 2019
$18.2M
Neuronal and glial interactions of neuropathic painR01DE017794 · NIDCR · DUKE UNIVERSITY · PI BUCHHEIT, THOMAS · 2006 to 2021
$6.6M
Hemichannels, Astrocytic Release, and Neuropathic PainR01DE022743 · NIDCR · DUKE UNIVERSITY · PI JI, RU-RONG, NEDERGAARD, MAIKEN · 2012 to 2016
$2.0M
Resolution pathway of painR01NS087988 · NINDS · DUKE UNIVERSITY · PI JI, RU-RONG · 2014 to 2018
$1.7M
NIDCR NIH HHS R01 DE017794NIDCR NIH HHS R01 DE022743NIGMS NIH HHS T32 GM007184NINDS NIH HHS R01 NS087988
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) remains a pressing clinical problem; however, our understanding of sexual dimorphism in CIPN remains unclear. Emerging studies indicate a sex-dimorphic role of Toll-like receptor 4 (TLR4) in driving neuropathic pain. In this study, we examined the role of TLR9 in CIPN induced by paclitaxel in WT and

Indexed as

AnimalsAntineoplastic AgentsFemaleHyperalgesiaMacrophagesMaleMiceNeuralgiaPaclitaxelPain MeasurementPain ThresholdPeripheral Nervous System DiseasesToll-Like Receptor 9Antineoplastic AgentsPaclitaxelToll-Like Receptor 9chemotherapyDRGmacrophagesneuropathic painsex dimorphismTLR9

Identifiers

PMID31270160
PMCPMC6733562
OpenAlexW2953447050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.