Evidence map›Paper›PMID 31270153›Full record

ArticleMolecular cancer therapeutics2019

Ileine M Sanchez, Timothy J Purwin, Inna Chervoneva, Dan A Erkes, Mai Q Nguyen, Michael A Davies, Katherine L Nathanson, Kristel Kemper, Daniel S Peeper, Andrew E Aplin

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Trametinib-Resistant Melanoma Cells Displaying MITFInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Review
  16. Review
  17. Intermittent treatment of BRAFProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Ileine M SanchezDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Timothy J PurwinDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0002-7053-8039
Inna ChervonevaDivision of Biostatistics, Sidney Kimmel Cancer Center at Jefferson, Philadelphia, Pennsylvania.
Dan A ErkesDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Mai Q NguyenDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Michael A DaviesDepartment of Melanoma Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-0977-0912
Katherine L NathansonTranslational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Kristel KemperDivision of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Daniel S PeeperDivision of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Andrew E AplinDepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. Andrew.Aplin@Jefferson.edu.ORCID 0000-0002-2734-3244
Thomas Jefferson University · USOncode Institute · NLSidney Kimmel Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Pennsylvania · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
Request for Supplemental Funds aligned to CA160495R01CA160495 · NCI · THOMAS JEFFERSON UNIVERSITY · PI APLIN, ANDREW ERIC · 2012 to 2022
$3.6M
Targeted therapies in mutant BRAF melanomaR01CA182635 · NCI · THOMAS JEFFERSON UNIVERSITY · PI APLIN, ANDREW ERIC · 2014 to 2024
$3.4M
NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA056036NCI NIH HHS R01 CA160495NCI NIH HHS R01 CA182635
6 · The paper itself

Abstract

Combined BRAF and MEK inhibition is a standard of care in patients with advanced BRAF-mutant melanoma, but acquired resistance remains a challenge that limits response durability. Here, we quantitated

Indexed as

AnimalsCell Cycle ProteinsCell Line, TumorDrug Resistance, NeoplasmExtracellular Signal-Regulated MAP KinasesGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMelanomaMice, NudeMitogen-Activated Protein Kinase KinasesMutationPolo-Like Kinase 1Protein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsBRAF protein, humanCell Cycle ProteinsExtracellular Signal-Regulated MAP KinasesMitogen-Activated Protein Kinase KinasesPolo-Like Kinase 1Protein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins B-raf

Identifiers

PMID31270153
PMCPMC6726573
OpenAlexW2955071179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.