Evidence map›Paper›PMID 31270135›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2019

Regulation of Bacterial Gene Expression by Transcription Attenuation.

Charles L Turnbough

Open access · bronzeAbstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Charles L TurnboughDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA chuckt@uab.edu.
University of Alabama at Birmingham · US

Funding

Bacterial gene regulation by the NTP substrates of transcription initiationR01GM094466 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TURNBOUGH, CHARLES LEE · 2010 to 2013
$1.1M
REGULATION OF PYRIMIDINE GENE EXPRESSION IN BACTERIAR01GM029466 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TURNBOUGH, CHARLES L. · 1985 to 2001
$604k
NIGMS NIH HHS R01 GM029466NIGMS NIH HHS R01 GM094466
6 · The paper itself

Abstract

A wide variety of mechanisms that control gene expression in bacteria are based on conditional transcription termination. Generally, in these mechanisms, a transcription terminator is located between a promoter and a downstream gene(s), and the efficiency of the terminator is controlled by a regulatory effector that can be a metabolite, protein, or RNA. The most common type of regulation involving conditional termination is transcription attenuation, in which the primary regulatory target is an essential element of a single terminator. The terminator can be either intrinsic or Rho dependent, with each presenting unique regulatory targets. Transcription attenuation mechanisms can be divided into five classes based primarily on the manner in which transcription termination is rendered conditional. This review summarizes each class of control mechanisms from a historical perspective, describes important examples in a physiological context and the current state of knowledge, highlights major advances, and discusses expectations of future discoveries.

Indexed as

Gene Expression Regulation, BacterialTranscription, GeneticBacteriaEscherichia coliGenes, BacterialRiboswitchRNA, BacterialRNA-Binding ProteinsRiboswitchRNA, BacterialRNA-Binding Proteinsbacterial gene regulationintrinsic terminationreiterative transcriptionRho-dependent terminationriboswitchesRNA-binding proteinstranscription attenuation

Identifiers

PMID31270135
PMCPMC6710462
OpenAlexW2954143028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.