Evidence map›Paper›PMID 31270082›Full record

ArticleBlood advances2019

Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms.

David E Schmidt, Katja M J Heitink-Pollé, Annemieke G Laarhoven, Marrie C A Bruin, Barbera Veldhuisen, Sietse Q Nagelkerke, Taco W Kuijpers, Leendert Porcelijn, C Ellen van der Schoot, Gestur Vidarsson and 1 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Evaluation ofFrontiers in medicine · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
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  9. Review
  10. Outcomes of Eltrombopag Treatment and Development of Iron Deficiency in Children with Immune Thrombocytopenia in TurkeyTurkish journal of haematology : official journal of Turkish Society of Haematology · 2020
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

David E SchmidtDepartment of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.ORCID 0000-0001-5555-376X
Katja M J Heitink-PolléDepartment of Pediatric Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Annemieke G LaarhovenDepartment of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.
Marrie C A BruinDepartment of Pediatric Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Barbera VeldhuisenDepartment of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.
Sietse Q NagelkerkeLandsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-8359-4016
Taco W KuijpersLandsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Leendert PorcelijnDepartment of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, The Netherlands.
C Ellen van der SchootDepartment of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.
Gestur VidarssonDepartment of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.ORCID 0000-0001-5621-003X
Masja de HaasDepartment of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, The Netherlands.
Sanquin · NLUniversity Medical Center Utrecht · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In childhood immune thrombocytopenia (ITP), anti-platelet autoantibodies mediate platelet clearance through Fc-γ receptor (FcγR)-bearing phagocytes. In 75% to 90% of patients, the disease has a transient, self-limiting character. Here we characterized how polymorphisms of FcγR genes affect disease susceptibility, response to intravenous immunoglobulin (IVIg) treatment, and long-term recovery from childhood ITP. Genotyping of the

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticAllelesBiomarkersChildChild, PreschoolFemaleGene FrequencyGenetic Association StudiesGenotypeHumansImmunoglobulins, IntravenousMaleOdds RatioPurpura, Thrombocytopenic, IdiopathicReceptors, IgGBiomarkersImmunoglobulins, IntravenousReceptors, IgG

Identifiers

PMID31270082
PMCPMC6616256
OpenAlexW2955445077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.