Evidence map›Paper›PMID 31269914›Full record

Trial reportBMC cancer2019

Feasibility of high intensity interval training in patients with breast Cancer undergoing anthracycline chemotherapy: a randomized pilot trial.

Kyuwan Lee, Irene Kang, Wendy J Mack, Joanne Mortimer, Fred Sattler, George Salem, Christina M Dieli-Conwright

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02454777 (High-Intensity Interval Training), which is not on this map. Cited by 48 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 11 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02454777 naterminatednot on this map

High-Intensity Interval Training (HIT) for Breast Cancer Patients During Trastuzumab Use

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2015 to 2019Enrolled31ConditionsStage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast CancerArmsExercise Intervention, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 11 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  6. Effect of therapeutic exercise on peak oxygen consumption in oncological population: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  9. Effect of aerobic exercise on cardiotoxic outcomes in women with breast cancer undergoing anthracycline or trastuzumab treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  15. Effect of high-intensity interval training on patient-reported outcomes and physical function in women with breast cancer receiving anthracycline-based chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kyuwan LeeDivision of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California (USC), 1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
Irene KangDepartment of Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, 90089, USA.
Wendy J MackDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, 90089, USA.
Joanne MortimerDivision of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.
Fred SattlerDivision of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California (USC), 1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
George SalemDivision of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California (USC), 1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
Christina M Dieli-ConwrightDivision of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California (USC), 1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA. cdieli@usc.edu.ORCID http://orcid.org/0000-0001-9093-7259
University of Southern California · USCity of Hope · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
NCATS NIH HHS UL1 TR001855NCATS NIH HHS UL1TR001855
6 · The paper itself

Abstract

backgroundAnthracycline-based chemotherapy is associated with reduced cardiorespiratory fitness in breast cancer patients. High intensity interval training (HIIT) induces greater benefits on cardiorespiratory fitness than moderate continuous aerobic exercise in patients with heart failure. The study purpose was to determine whether a HIIT intervention is a feasible exercise strategy for breast cancer patients undergoing anthracycline-based chemotherapy.

methodsThirty women were randomized to either HIIT or non-exercise control group (CON). Participants performed a maximal cycling fitness test to measure peak power output during maximal oxygen uptake (VO

resultsParticipants were 46.9 ± 9.8 (mean ± SD) years old, diagnosed with clinical stage II (30%) or III (63%) breast cancer. The average weekly minutes of exercise completed was 78 ± 5.1 out of 90 min. Twelve of 15 participants met both feasibility criteria, attending 19.2 ± 2.1 out of 24 sessions (82.3%). VO

conclusionsHIIT is a feasible exercise intervention to maintain VO

trial registrationThe protocol and informed consent were approved by the institutional IRB (HS-12-00227) and registered ( ClinicalTrials.gov NCT02454777; date of registration: May 272,015).

Indexed as

High-Intensity Interval TrainingOxygen ConsumptionPhysical FitnessAnthracyclinesBreast NeoplasmsFeasibility StudiesFemaleHumansMiddle AgedPilot ProjectsAnthracyclinesAnthracyclineBreast cancerFeasibilityHigh intensity interval trainingPeak power output

Identifiers

PMID31269914
PMCPMC6610838
OpenAlexW2953984817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.