Evidence map›Paper›PMID 31269907›Full record

ArticleBMC cardiovascular disorders2019

Gender but not diabetes, hypertension or smoking affects infarct evolution in ST-elevation myocardial infarction patients - data from the CHILL-MI, MITOCARE and SOCCER trials.

David Nordlund, Henrik Engblom, Jean-Louis Bonnet, Henrik Steen Hansen, Dan Atar, David Erlinge, Ulf Ekelund, Einar Heiberg, Marcus Carlsson, Håkan Arheden

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

David NordlundDepartment of Clinical Physiology, Clinical Sciences, Lund University, Lund, Sweden.ORCID 0000-0002-6567-8459
Henrik EngblomDepartment of Clinical Physiology, Clinical Sciences, Lund University, Lund, Sweden.
Jean-Louis BonnetAssistance Publique Hôpitaux de Marseille, Hôpital La Timone, Marseille, France.
Henrik Steen HansenDepartment of Cardiology B, Odense University Hospital, Odense, Denmark.
Dan AtarDepartment of Cardiology B, Oslo University Hospital Ullevål, and Faculty of Medicine, University of Oslo, Oslo, Norway.
David ErlingeDepartment of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
Ulf EkelundDepartment of Emergency Medicine, Clinical Sciences, Lund University, Lund, Sweden.
Einar HeibergDepartment of Clinical Physiology, Clinical Sciences, Lund University, Lund, Sweden.
Marcus CarlssonDepartment of Clinical Physiology, Clinical Sciences, Lund University, Lund, Sweden.
Håkan ArhedenDepartment of Clinical Physiology, Clinical Sciences, Lund University, Lund, Sweden. hakan.arheden@med.lu.se.
Lund University · SEAssistance Publique Hôpitaux de Marseille · FROdense University Hospital · DKOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfarct evolution rate and response to acute reperfusion therapy may differ between patients, which is important to consider for accurate management and treatment of patients with ST-elevation myocardial infarction (STEMI). The aim of this study was therefore to investigate the association of infarct size and myocardial salvage with gender, smoking status, presence of diabetes or history of hypertension in a cohort of STEMI-patients.

methodsPatients (n = 301) with first-time STEMI from the three recent multi-center trials (CHILL-MI, MITOCARE and SOCCER) underwent cardiac magnetic resonance (CMR) imaging to determine myocardium at risk (MaR) and infarct size (IS). Myocardial salvage index (MSI) was calculated as MSI = 1-IS/MaR. Pain to balloon time, culprit vessel, trial treatments, age, TIMI grade flow and collateral flow by Rentrop grading were included as explanatory variables in the statistical model.

resultsWomen (n = 66) had significantly smaller MaR (mean difference: 5.0 ± 1.5% of left ventricle (LV), p < 0.01), smaller IS (mean difference: 5.1 ± 1.4% of LV, p = 0.03), and larger MSI (mean difference: 9.6 ± 2.8% of LV, p < 0.01) compared to men (n = 238). These differences remained significant when adjusting for other explanatory variables. There were no significant effects on MaR, IS or MSI for diabetes, hypertension or smoking.

conclusionsFemale gender is associated with higher myocardial salvage and smaller infarct size suggesting a pathophysiological difference in infarct evolution between men and women.

Indexed as

Health Status DisparitiesAgedDiabetes MellitusFemaleHumansHypertensionMaleMiddle AgedMulticenter Studies as TopicMyocardial ReperfusionMyocardiumRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsSex FactorsSmokingArea at riskDiabetesGenderHypertensionSex

Identifiers

PMID31269907
PMCPMC6610840
OpenAlexW2953549646

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.