Trial reportActa orthopaedica2019
Bone remodeling of the proximal tibia after uncemented total knee arthroplasty: secondary endpoints analyzed from a randomized trial comparing monoblock and modular tibia trays-2 year follow-up of 53 cases.
Trial report in Acta orthopaedica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Factors influencing periprosthetic bone mineral density in total knee arthroplasty: a systematic review.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Trabecular metal monoblock versus modular tibial trays in total knee arthroplasty: meta-analysis of randomized control trials.International orthopaedics · 2022Pooled it
- Change in bone mineral density after cemented and uncemented knee arthroplasty with an asymmetrical tibial component: secondary analysis of a randomized study using dual-energy X-ray absorptiometry.Acta orthopaedica · 2026Trial
- A novel method of determining bone mineral density of the knee from a pre-surgical CT scan to aid in surgical planning.Osteoarthritis imaging · 2026Article
- Joint Reaction Forces Decrease Following Total Knee Arthroplasty up to 12-Months Post-Surgery.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Can Hounsfield Unit Evaluation of Preoperative CT Scans Predict Surgeon's Preference of Cementless Fixation in Total Knee Arthroplasty?Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Changes in Periprosthetic Bone Mineral Density Following Arthroplasty: An In-Depth Review and Current Perspectives.Current osteoporosis reports · 2025Review
- Variations in bone mineral density after joint replacement: A systematic review examining different anatomical regions, fixation techniques and implant design.Journal of experimental orthopaedics · 2025Review
- Tibial periprosthetic fractures in Total Knee Arthroplasty - A scoping review.Journal of clinical orthopaedics and trauma · 2022Article
- Bone remodeling and implant migration of uncemented femoral and cemented asymmetrical tibial components in total knee arthroplasty - DXA and RSA evaluation with 2-year follow up.Knee surgery & related research · 2021Article
- Quantitative measurements of adaptive bone remodeling around the cemented Zimmer® segmental stem after tumor resection arthroplasty using dual-energy x-ray absorptiometry.BMC musculoskeletal disorders · 2021Article
- The clinical outcomes of cementless unicompartmental knee replacement in patients with reduced bone mineral density.Journal of orthopaedic surgery and research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose - Bone remodeling as a response to bone trauma, postoperative immobilization, and device-related bone reactions can lead to loss of bone stock and increase the risk of periprosthetic fracture and aseptic loosening. This study investigates the adaptive bone remodeling of the proximal tibia after uncemented total knee arthroplasty (TKA). Patients and methods - We performed a 2-year follow up of 53 patients (mean age 62 (38-70) years, 27 of whom were men, who received an uncemented TKA in a randomized controlled trial with bone mineral density (BMD) as secondary endpoint. Patients were randomized to 2 groups of either monoblock (A) or modular (B) polyethylene design. The TKAs were performed using the uncemented Zimmer Nexgen trabecular metal. Measurements of BMD were done postoperatively and after 3, 6, 12, and 24 months. BMD was measured in 3 regions of interest (ROI). Results and interpretation - In group A statistically significant changes in BMD were seen after 24 months in both the medial and lateral ROI. BMD decreased medially by 15% (p = 0.004) and laterally by 13% (p = 0.01). In group B the BMD changes were limited and after 24 months returned to the preoperative values. The differences in BMD change between groups were statistically significant in both the medial (p = 0.03) and lateral (p = 0.02) ROI. In the distal ROI we found no significant change in BMD in either group. A significantly different bone remodeling pattern of the proximal tibia was seen in the 2 groups with a higher degree of bone loss in the knees that received the monoblock polyethylene design, indicating that the flexible monoblock implant design, previously shown to improve fixation, does not decrease the bone loss of the proximal tibia.
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