ArticleMetabolites2019
A Single Visualization Technique for Displaying Multiple Metabolite-Phenotype Associations.
Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Procalcitonin metabolomics in the critically ill reveal relationships between inflammation intensity and energy utilization pathways.Scientific reports · 2021Trial
- Metabolomic basis for response to high dose vitamin D in critical illness.Clinical nutrition (Edinburgh, Scotland) · 2021Trial
- Lifespan trajectories of serum sphingolipids in a clinically healthy Swiss population, towards precision medicine in cardiometabolic health assessment.Communications medicine · 2026Article
- Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study.Critical care (London, England) · 2022Article
- Uncovering PFAS and Other Xenobiotics in the Dark Metabolome Using Ion Mobility Spectrometry, Mass Defect Analysis, and Machine Learning.Environmental science & technology · 2022Article
- Sex-Specific Catabolic Metabolism Alterations in the Critically Ill following High Dose Vitamin D.Metabolites · 2022Article
- FlexDotPlot: a universal and modular dot plot visualization tool for complex multifaceted data.Bioinformatics advances · 2022Article
- Metabolic View on Human Healthspan: A Lipidome-Wide Association Study.Metabolites · 2021Article
- Metabolomic differences between critically Ill women and men.Scientific reports · 2021Article
- Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights.Frontiers in cardiovascular medicine · 2021Article
- Article
- Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS).International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
To assist with management and interpretation of human metabolomics data, which are rapidly increasing in quantity and complexity, we need better visualization tools. Using a dataset of several hundred metabolite measures profiled in a cohort of ~1500 individuals sampled from a population-based community study, we performed association analyses with eight demographic and clinical traits and outcomes. We compared frequently used existing graphical approaches with a novel 'rain plot' approach to display the results of these analyses. The 'rain plot' combines features of a raindrop plot and a conventional heatmap to convey results of multiple association analyses. A rain plot can simultaneously indicate effect size, directionality, and statistical significance of associations between metabolites and several traits. This approach enables visual comparison features of all metabolites examined with a given trait. The rain plot extends prior approaches and offers complementary information for data interpretation. Additional work is needed in data visualizations for metabolomics to assist investigators in the process of understanding and convey large-scale analysis results effectively, feasibly, and practically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.