ArticleMetabolites2019
The Search for Clinically Useful Biomarkers of Complex Disease: A Data Analysis Perspective.
Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis.Arthritis research & therapy · 2024Pooled it
- Benchmarking large language models for cell-free RNA diagnostic biomarker discovery.Nature communications · 2026Article
- Attachment as a Primary Mechanism in Physician Cognition and Bias During Complex Medical Cases: A Narrative Review.Advances in medical education and practice · 2025Review
- Denoising magnetic resonance spectroscopy (MRS) data using stacked autoencoder for improving signal-to-noise ratio and speed of MRS.Medical physics · 2023Article
- The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates.Antioxidants (Basel, Switzerland) · 2023Review
- Current State and Future Perspectives on Personalized Metabolomics.Metabolites · 2023Review
- Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests.Analytical and bioanalytical chemistry · 2022Review
- Defining Blood Plasma and Serum Metabolome by GC-MS.Metabolites · 2021Review
- Article
- Metabolomic Laboratory-Developed Tests: Current Status and Perspectives.Metabolites · 2021Review
- Dried Blood Spot (DBS) Methodology Study for Biomarker Discovery in Lysosomal Storage Disease (LSD).Metabolites · 2021Article
- Spectral Wavelet-feature Analysis and Classification Assisted Denoising for enhancing magnetic resonance spectroscopy.NMR in biomedicine · 2021Article
- Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review.Metabolites · 2021Review
- Mass spectrometry in clinical glycomics: The path from biomarker identification to clinical implementation.Clinical mass spectrometry (Del Mar, Calif.) · 2020Review
- Five Easy Metrics of Data Quality for LC-MS-Based Global Metabolomics.Analytical chemistry · 2020Article
- Prediction of preeclampsia risk in first time pregnant women: Metabolite biomarkers for a clinical test.PloS one · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Unmet clinical diagnostic needs exist for many complex diseases, which (it is hoped) will be solved by the discovery of metabolomics biomarkers. However, at present, no diagnostic tests based on metabolomics have yet been introduced to the clinic. This review is presented as a research perspective on how data analysis methods in metabolomics biomarker discovery may contribute to the failure of biomarker studies and suggests how such failures might be mitigated. The study design and data pretreatment steps are reviewed briefly in this context, and the actual data analysis step is examined more closely.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.