Evidence map›Paper›PMID 31269510›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.

Yasmin Zakiniaeiz, Ansel T Hillmer, David Matuskey, Nabeel Nabulsi, Jim Ropchan, Carolyn M Mazure, Marina R Picciotto, Yiyun Huang, Sherry A McKee, Evan D Morris and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
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  6. Lower Striatal Dopamine D2 Receptor Availability in Individuals Who Test Positive for Quantitated Urine Metabolites of Tobacco and/or Marijuana Smoke.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yasmin ZakiniaeizDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Ansel T HillmerDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Nabeel NabulsiYale Positron Emission Tomography (PET) Center, Yale University, New Haven, CT, USA.
Jim RopchanYale Positron Emission Tomography (PET) Center, Yale University, New Haven, CT, USA.
Carolyn M MazureDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Marina R PicciottoDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4404-1280
Yiyun HuangYale Positron Emission Tomography (PET) Center, Yale University, New Haven, CT, USA.
Sherry A McKeeDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Evan D MorrisDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Kelly P CosgroveDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA. kelly.cosgrove@yale.edu.
Itron (United States) · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale SCOR on Gender-Sensitive Treatment for Tobacco DependenceP50DA033945 · NIDA · YALE UNIVERSITY · PI MCKEE, SHERRY ANN · 2012 to 2017
$6.5M
Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Anatomical basis for nicotine addiction in miceR01DA014241 · NIDA · YALE UNIVERSITY · PI PICCIOTTO, MARINA R · 2001 to 2018
$5.2M
Imaging Molecular Mechanisms of Tobacco Smoking WithdrawalR01DA038832 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2016 to 2021
$3.6M
Anatomical Basis for Nicotine AddictionR37DA014241 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2020 to 2026
$2.7M
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894k
Imaging Genetics in Tobacco SmokersK02DA031750 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2012 to 2016
$634k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIDA NIH HHS K02 DA031750NIDA NIH HHS P50 DA033945NIDA NIH HHS R01 DA014241NIDA NIH HHS R01 DA038832NIDA NIH HHS R37 DA014241NIDA NIH HHS T32 DA022975
6 · The paper itself

Abstract

Sex differences exist in the neurochemical mechanisms underlying tobacco smoking and smoking-related behaviors. Men tend to smoke for the reinforcing effects of nicotine, whereas women tend to smoke for stress and mood regulation, and have a harder time maintaining long-term abstinence. The mesolimbic dopamine (DA) system drives the reinforcing effects of tobacco smoking, whereas the mesocortical DA system-including the dorsolateral prefrontal cortex (dlPFC)-is critical for stress-related cognitive functioning and inhibitory control. This study is the first to investigate dlPFC D

Indexed as

Sex CharacteristicsSmokersAdultAmphetamineDopamineFemaleHumansMalePositron-Emission TomographyPrefrontal CortexReceptors, Dopamine D2AmphetamineDopamineDRD2 protein, humanReceptors, Dopamine D2

Identifiers

PMID31269510
PMCPMC6897943
OpenAlexW2954022213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.