Evidence map›Paper›PMID 31269439›Full record

ArticleCell reports2019

Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury.

Weibin Cai, Jing Tan, Jianyun Yan, Lu Zhang, Xiaoqiang Cai, Haiping Wang, Fang Liu, Maoqing Ye, Chen-Leng Cai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  7. Animal models to study cardiac regeneration.Nature reviews. Cardiology · 2024
    Review
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  14. Towards precision medicine in heart failure.Nature reviews. Cardiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Weibin CaiDepartment of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Biochemistry, Guangdong Engineering & Technology Research Center for Disease-Model Animals, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China. Electronic address: caiwb@mail.sysu.edu.cn.
Jing TanDepartment of Biochemistry, Guangdong Engineering & Technology Research Center for Disease-Model Animals, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
Jianyun YanDepartment of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Lu ZhangDepartment of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, Indiana 46202, USA.
Xiaoqiang CaiDepartment of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Haiping WangDepartment of Biochemistry, Guangdong Engineering & Technology Research Center for Disease-Model Animals, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
Fang LiuCardiovascular Center, Children's Hospital of Fudan University, Shanghai 201102, China.
Maoqing YeShanghai Key Laboratory of Clinical Geriatric Medicine, Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Chen-Leng CaiDepartment of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, Indiana 46202, USA. Electronic address: chenleng@iu.edu.
Sun Yat-sen University · CNIcahn School of Medicine at Mount Sinai · USIndiana University School of MedicineChildren's Hospital of Fudan University · CNFudan University · CN

Funding

Genetic and Molecular Investigation of Tbx20 in Cardiac DevelopmentR01HL095810 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, CHENLENG · 2010 to 2014
$2.1M
T-box transcription factor Tbx2 in coronary vascular development and diseaseR01HL131735 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CAI, CHENLENG · 2017 to 2020
$2.0M
Deciphering the mechanisms of c-kit+ cells in heart repairR01HL137036 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI SHOU, WEINIAN · 2018 to 2021
$1.6M
T-Box Transcription Factor Tbx20 in Cardiac Development, Function and DiseaseK02HL094688 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, CHENLENG · 2009 to 2013
$512k
NHLBI NIH HHS K02 HL094688NHLBI NIH HHS R01 HL095810NHLBI NIH HHS R01 HL131735NHLBI NIH HHS R01 HL137036
6 · The paper itself

Abstract

The regeneration capacity of neonatal mouse heart is controversial. In addition, whether epicardial cells provide a progenitor pool for de novo heart regeneration is incompletely defined. Following apical resection of the neonatal mouse heart, we observed limited regeneration potential. Fate-mapping of Tbx18

Indexed as

AnimalsAnimals, NewbornCell DifferentiationCell LineageCoronary VesselsEndothelial CellsGene Knock-In TechniquesHeartHeart InjuriesMiceMyocytes, CardiacNeovascularization, PhysiologicPericardiumRegenerationStem CellsT-Box Domain ProteinsT-Box Domain ProteinsTbx18 protein, mousecell lineage tracingepicardial cellsheart regenerationneonatal mouse

Identifiers

PMID31269439
PMCPMC6837841
OpenAlexW2956154114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.