ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2019
Antileishmanial activity of Melampodium divaricatum and Casearia sylvestris essential oils on Leishmania amazonensis.
Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Potential Effects of Essential Oil fromMicroorganisms · 2024Article
- Chemical Composition and In Vitro and In Silico Antileishmanial Evaluation of the Essential Oil fromAntibiotics (Basel, Switzerland) · 2022Article
- Antibacterial, Antiparasitic, and Cytotoxic Activities of Chemical Characterized Essential Oil ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Phytochemical Profile and Herbicidal (Phytotoxic), Antioxidants Potential of Essential Oils fromMolecules (Basel, Switzerland) · 2022Article
- Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites.Molecules (Basel, Switzerland) · 2022Article
- Chemical Composition and Antifungal Activity ofMolecules (Basel, Switzerland) · 2021Article
- Chemical Composition and Antioxidant Activity of Essential Oils from Leaves of Two Specimens ofMolecules (Basel, Switzerland) · 2021Article
- Cytotoxicity of Essential OilMolecules (Basel, Switzerland) · 2021Article
- Chemical Composition and Antioxidant Activity of Essential Oils fromMolecules (Basel, Switzerland) · 2021Article
- Arginase/nitric oxide modifications using live non-pathogenicJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- (-)-T-Cadinol-a Sesquiterpene Isolated FromFrontiers in pharmacology · 2021Article
- Green Approach: ''A Forwarding Step for Curing Leishmaniasis-A Neglected Tropical Disease''.Frontiers in molecular biosciences · 2021Review
- Effects of vitamin A and vitamin E on attenuation of amphotericin B-induced side effects on kidney and liver of male Wistar rats.Environmental science and pollution research international · 2020Article
- Antileishmanial Compounds Isolated fromMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leishmaniasis is a disease that affects millions of people and it is an important public health problem. The drugs currently used for the treatment of leishmaniasis present undesirable side effects and low efficacy. In this study, we evaluated the in vitro activity of Melampodium divaricatum (MD-EO) and Casearia sylvestris (CS-EO) essential oils (EO) against promastigote and amastigote forms of Leishmania amazonensis. Sesquiterpenes E-caryophyllene (56.0%), germacrene D (12.7%) and bicyclogermacrene (9.2%) were identified as the main components of MD-EO, whereas E-caryophyllene (22.2%), germacrene D (19.6%) and bicyclogermacrene (12.2%) were the main constituents of CS-EO. CS-EO and E-caryophyllene were active against promastigote forms of L. amazonensis (IC50 24.2, 29.8 and 49.9 µg/mL, respectively). However, MD-EO, CS-EO and E-caryophyllene were more active against amastigote forms, with IC50 values of 10.7, 14.0, and 10.7 µg/mL, respectively. E-caryophyllene presented lower cytotoxicity against macrophages J774-A1 (CC50 of 62.1 µg/mL) than the EO. The EOs and E-caryophyllene should be further studied for the development of new antileishmanial drugs.
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