ArticlePloS one2019
Encoding information in synthetic metabolomes.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Storing Data With Propargylic Amines Using Thin-Layer Chromatography for the Data Retrieval.ChemPlusChem · 2026Article
- DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025Review
- Article
- A dual-rule encoding DNA storage system using chaotic mapping to control GC content.Bioinformatics (Oxford, England) · 2024Article
- Molecular data storage using direct analysis in real time (DART) ionization mass spectrometry for decoding.Scientific reports · 2023Article
- Digital circuits and neural networks based on acid-base chemistry implemented by robotic fluid handling.Nature communications · 2023Article
- A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning.Frontiers in computational neuroscience · 2023Article
- Molecular data storage with zero synthetic effort and simple read-out.Scientific reports · 2022Article
- Secret messaging with endogenous chemistry.Scientific reports · 2021Article
- The visual story of data storage: From storage properties to user interfaces.Computational and structural biotechnology journal · 2021Review
- DNA storage: research landscape and future prospects.National science review · 2020Article
- Encoding Information into Polyethylene Glycol Using an Alcohol-Isocyanate "Click" Reaction.International journal of molecular sciences · 2020Article
- Multicomponent molecular memory.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomolecular information systems offer exciting potential advantages and opportunities to complement conventional semiconductor technologies. Much attention has been paid to information-encoding polymers, but small molecules also play important roles in biochemical information systems. Downstream from DNA, the metabolome is an information-rich molecular system with diverse chemical dimensions which could be harnessed for information storage and processing. As a proof of principle of small-molecule postgenomic data storage, here we demonstrate a workflow for representing abstract data in synthetic mixtures of metabolites. Our approach leverages robotic liquid handling for writing digital information into chemical mixtures, and mass spectrometry for extracting the data. We present several kilobyte-scale image datasets stored in synthetic metabolomes, which can be decoded with accuracy exceeding 99% using multi-mass logistic regression. Cumulatively, >100,000 bits of digital image data was written into metabolomes. These early demonstrations provide insight into some of the benefits and limitations of small-molecule chemical information systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.