Evidence map›Paper›PMID 31268937›Full record

ArticleJournal of occupational and environmental medicine2019

Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.

Prerna Khetan, Paolo Boffetta, Daniele Luce, Isabelle Stucker, Maria Paula Curado, Ana Menezes, Victor Wunsch-Filho, Wolfgang Ahrens, Pagona Lagiou, Diego Serraino and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Immunotherapy in Head and Neck Cancer.Cancer treatment and research · 2025
    Review
  6. Article
  7. Observational
  8. Article
  9. [Advances in risk factors and genetic risk of head and neck squamous cell carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Prerna KhetanThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York (Dr Khetan, Dr Boffetta, Dr Hashim); University of Rennes, National Institute of Health and Medical Research, School of Advanced Studies in Public Health, Institute for Health, Environment and Work Research - Research Unit UMR_S 1085, Pointe-à-Pitre, France (Dr Luce); Cancer and Environment Team, National Institute of Health and Medical Research U1018, Paris-Sud University, Paris-Saclay University, Villejuif, France (Dr Stucker); Cancer and Environment team (CESP), (Inserm) National Institute of Health and Medical Research U1018, Paris-Sud University, Paris-Saclay University, Villejuif, France (Dr Stucker); Federal University of Pelotas, Pelotas (Dr Menezes); University of Sao Paulo, Sao Paulo, Brazil (Dr Wunsch-Filho); Leibniz Institute for Prevention Research and Epidemiology, Bremen Institute for Prevention Research and Social Medicine , Bremen, Germany (Dr Ahrens); School of Medicine, National and Kapodistrian University of Athens, Greece (Dr Lagiou); Oncological Reference Center, Institute of Scientific Characterization and Hospitalization, Aviano, Italy (Dr Serraino); Department of Medical Sciences, University of Turin, Turin (Dr Richiardi); Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway (Dr Kjaerheim); School of Medicine, Dentistry, and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK (Dr Conway); University of Hong Kong, Hong Kong, China (Dr Thomson); Penn State College of Medicine, Hershey, Pennsylvania (Dr Muscat); National Institute of Public Health, Bucharest, Romania (Dr Mates); University of Heidelberg (Dr Ramroth); National Institute of Health and Medical Research, Sorbonne University, Pierre Louis Institute of Epidemiology and Public Health, Paris, France (Dr Menvielle); Fred Hutchinson Cancer Research Center, Seattle, Washington (Dr Vaughan); Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany (Dr Brenner); Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany (Dr Brenner); German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany Hermann Brenner (Dr Brenner); Division of Public Health, Department of Family & Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah (Dr Lee, Dr Hashibe); Department of Clinical Sciences and Community Health, University of Milan, Milan (Dr La Vecchia), Italy.
Paolo Boffetta
Daniele Luce
Isabelle Stucker
Maria Paula Curado
Ana Menezes
Victor Wunsch-Filho
Wolfgang Ahrens
Pagona Lagiou
Diego Serraino
Lorenzo Richiardi
Kristina Kjaerheim
David Conway
Peter Thomson
Joshua Muscat
Dana Mates
Heribert Ramroth
Gwenn Menvielle
Thomas L Vaughan
Hermann Brenner
Yuan-Chin Amy Lee
Carlo La Vecchia
Mia Hashibe
Dana Hashim

Funding

UDP GLUCURONOSYLTRANSFERASES, DETOXIFICATION OF NNKP01CA068384 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LAZARUS, PHILIP · 1995 to 2005
$8.5M
UDPGLUCURONOSYLTRANSFERASE GENOTYPE AND ORAL CANCER RISKR01DE013158 · NIDCR · UNIVERSITY OF SOUTH FLORIDA · PI LAZARUS, PHILIP · 2000 to 2011
$3.6M
Epidemiology of protein glutathiolationK07CA104231 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MUSCAT, JOSHUA E · 2005 to 2009
$681k
Pooled Analyses of SNPs and Risk of Head &Neck CancerR03DE016611 · NIDCR · INTERNATIONAL AGENCY FOR RES ON CANCER · PI HASHIBE, MIA · 2005 to 2006
$223k
International Head and Neck Cancer ConsortiumR03CA113157 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI HASHIBE, MIA · 2004 to 2005
$118k
INHANCE ConsortiumR13CA210555 · NCI · UNIVERSITY OF UTAH · PI HASHIBE, MIA · 2017 to 2018
$37k
ALCOHOL AND CANCERS OF THE LARYNX AND ESOPHAGUSR01CA030022 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI THOMAS, DAVID DALE · 1985 to 1987
–
NCI NIH HHS K07 CA104231NCI NIH HHS P01 CA068384NCI NIH HHS R01 CA030022NCI NIH HHS R03 CA113157NCI NIH HHS R13 CA210555NIDCR NIH HHS R01 DE013158NIDCR NIH HHS R03 DE016611
6 · The paper itself

Abstract

objectiveTo investigate the associations between head and neck cancer (HNC) risk and occupations.

methodsWe harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC × (OR - 1)/OR.

resultsTrend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR = 1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR = 1.38; 95% CI 1.13 to 1.69), painters (OR = 1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.

conclusionsWe found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.

Indexed as

Databases, FactualEuropeHead and Neck NeoplasmsHumansLatin AmericaLogistic ModelsNorth AmericaOccupational DiseasesRisk Factors

Identifiers

PMID31268937
PMCPMC6613803

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.