Evidence map›Paper›PMID 31268916›Full record

ArticleThe American journal of gastroenterology2019

Psychobiotics: Shaping the Mind With Gut Bacteria.

Jonathan P Jacobs, Emeran A Mayer

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in The American journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jonathan P JacobsDivision of Gastroenterology, Hepatology and Parenteral Nutrition, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Emeran A MayerG. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical and a few clinical studies have demonstrated the existence of a brain-gut-microbiome axis in which bacterial signals can modulate affective behavior, brain activity, and central gene expression profiles. The study by Wang et al. in this issue (Wang H, Braun C, Murphy EF, et al. Bifidobacterium longum 1714™ strain modulates brain activity of healthy volunteers during social stress. Am J Gastroenterol 2019;114:1152-62.) contributes to a growing body of literature demonstrating that probiotics that alter behavior in animal models-termed "psychobiotics"-can induce changes in human brain networks involved in emotional or cognitive responses. Although there are still many unknowns about the potential of existing probiotics to induce clinically relevant effects, these findings support continued investigation into interventions acting on the brain-gut-microbiome axis for affective, cognitive, and behavioral disorders.

Indexed as

Bifidobacterium longumGastrointestinal MicrobiomeProbioticsAnimalsBacteriaBrainHealthy VolunteersHumans

Identifiers

PMID31268916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.