ArticleThe Clinical journal of pain2019
Patient and Disease Characteristics Associate With Sensory Testing Results in Chronic Pancreatitis.
Article in The Clinical journal of pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Pooled it
- Static and dynamic quantitative sensory testing in chronic pancreatitis: Relation of pain sensitization to patient-reported outcomes and psychiatric comorbidities.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Trajectories of Pain Processing in Recurrent Acute and Chronic Pancreatitis: A Longitudinal Quantitative Sensory Testing Study.European journal of pain (London, England) · 2026Observational
- Electrophysiological biomarkers for foundational signal markers in chronic pancreatitis using machine learning models.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- An Ultrasound-Guided Thoracolumbar Erector Spinae Plane Block: An Experimental Preliminary Study in Horses.Animals : an open access journal from MDPI · 2025Article
- 16. Pain in chronic pancreatitis.Pain practice : the official journal of World Institute of Pain · 2025Review
- Recent advances in the understanding and management of chronic pancreatitis pain.Journal of pancreatology · 2024Review
- Spinal Excitability in Patients with Painful Chronic Pancreatitis.Journal of pain research · 2023Article
- Pancreatic QST Differentiates Chronic Pancreatitis Patients into Distinct Pain Phenotypes Independent of Psychiatric Comorbidities.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Review
- Gastrointestinal pain.Nature reviews. Disease primers · 2020Review
- Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbdominal pain is the most common symptom in chronic pancreatitis (CP) and has an extensive impact on patients' lives. Quantitative sensory testing (QST) provides information on sensitivity to pain and mechanisms that can help quantify pain and guide treatment. The aims of this study were (1) to explore sensitivity to pain in patients with CP using QST and (2) to associate patient and disease characteristics with QST results.
methodsNinety-one patients with painful CP and 28 healthy control participants completed a QST paradigm using static tests (muscle pressure stimulation and electrical skin stimulations) to unravel segmental and widespread hyperalgesia as a consequence of visceral pain. A dynamic conditioned pain modulation (CPM) paradigm was used as a proxy of pain modulation from the brainstem to inhibit incoming nociceptive barrage, and questionnaires were used to gather information on pain experience and quality of life.
resultsPatients had impaired CPM compared with controls (18.0±29.3% vs. 30.9±29.3%, P=0.04) and were hypersensitive to pressure stimulation, specifically in the pancreatic (Th10) dermatome (P<0.001). The capacity of CPM was associated with clinical pain intensity (P=0.01) and (in the univariate analysis only) the use of opioids was associated with hyperalgesia to pressure stimulation (P<0.05).
conclusionsSensitivity to pain in CP patients can be characterized by a simple bedside QST. Severe clinical pain in CP was associated with reduced CPM function and should be targeted in management.
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