Evidence map›Paper›PMID 31268630›Full record

ArticleMolecular genetics & genomic medicine2019

Haplotype analysis of SERPINE1 gene: Risk for aneurysmal subarachnoid hemorrhage and clinical outcomes.

Mingkuan Lin, Christoph J Griessenauer, Robert M Starke, R Shane Tubbs, Mohammadali M Shoja, Paul M Foreman, Nilesh A Vyas, Beverly C Walters, Mark R Harrigan, Philipp Hendrix and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Mingkuan LinDepartment of Systems Biology, George Mason University, Fairfax, Virginia.ORCID 0000-0003-3895-9148
Christoph J GriessenauerDepartment of Neurosurgery, Geisinger, Danville, Pennsylvania.
Robert M StarkeDepartment of Neurosurgery and Radiology, University of Miami, Miami, Florida.
R Shane TubbsChildren's of Alabama, Birmingham, Alabama.
Mohammadali M ShojaChildren's of Alabama, Birmingham, Alabama.
Paul M ForemanDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama, Alabama.
Nilesh A VyasDepartment of Neuroscience, INOVA Health System, Fairfax, Virginia.
Beverly C WaltersDepartment of Neuroscience, INOVA Health System, Fairfax, Virginia.
Mark R HarriganDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama, Alabama.
Philipp HendrixDepartment of Neurosurgery, Saarland University Medical Center, Saarland University, Homburg, Germany.
Winfield S FisherDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama, Alabama.
Jean-Francois PittetDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama, Alabama.
Mali MathruDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama, Alabama.
Robert H LipskyDepartment of Systems Biology, George Mason University, Fairfax, Virginia.
University of Alabama at Birmingham · USInova Health System · USChildren's of Alabama · USGeisinger Medical Center · USSaarland University · DEUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAneurysmal subarachnoid hemorrhage (aSAH) has high fatality and permanent disability rates due to the severe damage to brain cells and inflammation. The SERPINE1 gene that encodes PAI-1 for the regulation of tissue plasminogen activator is considered an important therapeutic target for aSAH.

methodsSix SNPs in the SERPINE1 gene (in order of rs2227631, rs1799889, rs6092, rs6090, rs2227684, rs7242) were investigated. Blood samples were genotyped with Taqman genotyping assays and pyrosequencing. The experiment-wide statistically significant threshold for single marker analysis was set at p < 0.01 after evaluation of independent markers. Haplotype analysis was performed in Haplo.stats package with permutation tests. Bonferroni correction for multiple comparison in dominant, additive, and recessive model was applied.

resultsA total of 146 aSAH patients and 49 control subjects were involved in this study. The rs2227631 G allele is significant (p = 0.01) for aSAH compared to control. In aSAH group, haplotype analysis showed that G5GGGT homozygotes in recessive model were associated with delayed cerebral ischemia (p < 0.01, Odds Ratio = 5.14, 95% CI = 1.45-18.18), clinical vasospasm (p = 0.01, Odds Ratio = 4.58, 95% CI = 1.30-16.13), and longer intensive care unit stay (p = 0.01). By contrast, the G5GGAG carriers were associated with less incidence of cerebral edema (p < 0.01) and higher Glasgow Coma Scale (p < 0.01). The A4GGGT carriers were associated with less incidence of severe hypertension (>140/90) (p < 0.01).

conclusionThe results suggested an important regulatory role of the SERPINE1 gene polymorphism in clinical outcomes of aSAH.

Indexed as

HaplotypesAllelesBrain EdemaBrain IschemiaCase-Control StudiesGenetic Predisposition to DiseaseGenotypeGlasgow Coma ScaleHumansHypertensionIncidenceOdds RatioPlasminogen Activator Inhibitor 1Polymorphism, Single NucleotideSubarachnoid HemorrhageTissue Plasminogen ActivatorPlasminogen Activator Inhibitor 1SERPINE1 protein, humanTissue Plasminogen Activatorclinical vasospasmDelayed Cerebral IschemiaSERPINE1Subarachnoid Hemorrhagetissue plasminogen activator

Identifiers

PMID31268630
PMCPMC6687628
OpenAlexW2954789385

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.