Evidence map›Paper›PMID 31268615›Full record

ArticleHuman brain mapping2019

Modulating functional connectivity between medial frontopolar cortex and amygdala by inhibitory and excitatory transcranial magnetic stimulation.

Philipp Riedel, Matthias Heil, Stephan Bender, Gabriel Dippel, Franziska M Korb, Michael N Smolka, Michael Marxen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Adolescent Distress: Is There a Vaccine? Social and Cultural Considerations during the COVID-19 Pandemic.International journal of environmental research and public health · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Philipp RiedelDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Matthias HeilDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Stephan BenderMedical Faculty, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Cologne, Germany.
Gabriel DippelDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany.
Franziska M KorbDepartment of General Psychology, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Michael MarxenDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-8870-0041
Technische Universität Dresden · DEUniversity Hospital Carl Gustav Carus · DEUniversity of Cologne · DE

Funding

Deutsche Forschungsgemeinschaft SFB 940/1Deutsche Forschungsgemeinschaft SFB 940/2
6 · The paper itself

Abstract

The prefrontal-limbic network in the human brain plays a major role in social cognition, especially cognitive control of emotion. The medial frontopolar cortex (mFP; Brodmann Area 10) and the amygdala are part of this network and display correlated neuronal activity in time, as measured by functional magnetic resonance imaging (fMRI). This functional connectivity is dynamic, sensitive to training, and affected in mental disorders. However, the effects of neurostimulation on functional connectivity within this network have not yet been systematically investigated. Here, we investigate the effects of both low- and high-frequency repetitive transcranial magnetic stimulation (rTMS) to the right mFP on functional connectivity between mFP and amygdala, as measured with resting state fMRI (rsfMRI). Three groups of healthy participants received either low-frequency rTMS (1 Hz; N = 18), sham TMS (1 Hz, subthreshold; N = 18) or high-frequency rTMS (20 Hz; N = 19). rsfMRI was acquired before and after (separate days). We hypothesized a modulation of functional connectivity in opposite directions compared to sham TMS through adjustment of the stimulation frequency. Groups differed in functional connectivity between mFP and amygdala after stimulation compared to before stimulation (low-frequency: decrease, high-frequency: increase). Motion or induced changes in neuronal activity were excluded as confounders. Results show that rTMS is effective for increasing and decreasing functional coherence between prefrontal and limbic regions. This finding is relevant for social and affective neuroscience as well as novel treatment approaches in psychiatry.

Indexed as

AdolescentAdultAffectAmygdalaAnxietyBrain MappingConnectomeFemaleHumansMagnetic Resonance ImagingMaleModels, NeurologicalModels, PsychologicalNeural PathwaysNeuroimagingPrefrontal Cortexamygdalaemotionfrontopolar cortexfunctional connectivityresting state MRIsocial cognitiontranscranial magnetic stimulation

Identifiers

PMID31268615
PMCPMC6865431
OpenAlexW2954579665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.