Evidence map›Paper›PMID 31268605›Full record

ArticleThe EMBO journal2019

NLRP1 - One NLR to guard them all.

Carolyn A Lacey, Edward A Miao

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. The NLRP1 Inflammasome in Human Skin and Beyond.International journal of molecular sciences · 2020
    Review
  5. Review
  6. NLRP1 - One NLR to guard them all.The EMBO journal · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Carolyn A LaceyDepartment of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Edward A MiaoDepartment of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-7295-3490

Funding

Innate immune defenses against a cytosolic capsuleR01AI136920 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Edward A Miao · 2019 to 2026
$3.7M
NIAID NIH HHS R01 AI136920
6 · The paper itself

Abstract

Microbial pathogens can be detected by inflammasomes that induce inflammation and programmed cell death. Inflammasomes are sensors that survey cells for signs of compromise. One of these sensors, NLRP1, detects anthrax lethal toxin; however, the mechanism of NLRP1 activation has remained unknown. Here, Xu et al discover NLRP1 cleavage by lethal toxin induces the N-end rule, which targets NLRP1 for degradation. Surprisingly, the active inflammasome fragment escapes the proteasome and becomes an activate inflammasome itself.

Indexed as

AnthraxInflammasomesAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsHumansLigasesNLR ProteinsUbiquitinAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsInflammasomesLigasesNLRP1 protein, humanNLR ProteinsUbiquitin

Identifiers

PMID31268605
PMCPMC6600648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.