ArticleThe EMBO journal2019
Of seeds and supplements: structural insights into extended microRNA-target pairing.
Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Computational meta-analysis of ribosomal RNA fragments: potential targets and interaction mechanisms.Nucleic acids research · 2021Pooled it
- A Multi-Input Neural Network Model for Accurate MicroRNA Target Site Detection.Non-coding RNA · 2025Article
- Large-Scale Computational Discovery of Binding Motifs in tRNA Fragments.Frontiers in molecular biosciences · 2021Article
- Of seeds and supplements: structural insights into extended microRNA-target pairing.The EMBO journal · 2019Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metazoan micro(mi) RNAs guide Argonaute proteins to their targets via perfect pairing to the seed region, located near the 5' end of the miRNA. In this issue of The EMBO Journal, Sheu-Gruttadauria et al report the crystal structure of human Argonaute 2 in complex with both a miRNA and target RNA and show that miRNA 3' supplementary nucleotides can increase target affinity and may contribute more to miRNA-mediated silencing than is currently appreciated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.