ReviewAnnals of the New York Academy of Sciences2019
Vagal innervation of the stomach reassessed: brain-gut connectome uses smart terminals.
Review in Annals of the New York Academy of Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Short-Chain Fatty Acids in Microbiota-Gut-Brain Cross-Talk with a Focus on Amyotrophic Lateral Sclerosis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Gastroparesis Phenotyping: Current Methods and Emerging Opportunities With Magnetic Resonance Imaging.Neurogastroenterology and motility · 2026Review
- Anatomy and function of efferent and afferent vagal innervation of the stomach.Autonomic neuroscience : basic & clinical · 2026Review
- Peripheral non-invasive focused ultrasound alleviates constipation by reducing gastrointestinal inflammation.Experimental physiology · 2026Article
- Accelerating the development of bioelectronic medicine: outcomes and innovations from the NIH SPARC initiative.Bioelectronic medicine · 2026Review
- Context-Dependent Modulation of Epithelial Barrier Integrity and Intestinal Permeability by Transcutaneous Auricular Vagus Nerve Stimulation in Two Preclinical Models Mimicking Ulcerative Colitis and Crohn's Disease: A Descriptive Analysis.International journal of molecular sciences · 2026Article
- Brunner's Glands in the Duodenal Bulb Are Indirectly Innervated by Vagal Preganglionics That Connect With Cholinergic Enteric Neurons in the Myenteric Plexus.The Journal of comparative neurology · 2026Article
- Autonomic nervous system dysfunction in irritable bowel syndrome: pathophysiology and therapeutic implications.Frontiers in neuroscience · 2026Review
- Direct vagal input to the gastrointestinal tract and other viscera: Re-definition of autonomic neuroscience or experimental artifacts?Autonomic neuroscience : basic & clinical · 2025Review
- Transcriptome atlases of rat brain regions and their adaptation to diabetes resolution following gastrectomy in the Goto-Kakizaki rat.Molecular brain · 2025Article
- Interaction of the Vagus Nerve and Serotonin in the Gut-Brain Axis.International journal of molecular sciences · 2025Review
- Microbiota-gut-brain-axis: a new target of acupuncture therapy for post-stroke cognitive impairment.Frontiers in microbiology · 2025Review
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders.Frontiers in cellular and infection microbiology · 2025Review
- Oral and gut microbiome profiles in people with early idiopathic Parkinson's disease.Communications medicine · 2024Article
- The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota.Translational stroke research · 2024Review
- Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model.Journal of neural engineering · 2024Article
- Desensitizing the autonomic nervous system to mitigate anti-GD2 monoclonal antibody side effects.Frontiers in oncology · 2024Article
- Organization and morphology of calcitonin gene-related peptide-immunoreactive axons in the whole mouse stomach.The Journal of comparative neurology · 2023Article
- Spinal afferent innervation in flat-mounts of the rat stomach: anterograde tracing.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Brain-gut neural communications have long been considered limited because of conspicuous numerical mismatches. The vagus, the parasympathetic nerve connecting brain and gut, contains thousands of axons, whereas the gastrointestinal (GI) tract contains millions of intrinsic neurons in local plexuses. The numerical paradox was initially recognized in terms of efferent projections, but the number of afferents, which comprise the majority (≈ 80%) of neurites in the vagus, is also relatively small. The present survey of recent morphological observations suggests that vagal terminals, and more generally autonomic and visceral afferent arbors in the stomach as well as throughout the gut, elaborate arbors that are extensive, regionally specialized, polymorphic, polytopic, and polymodal, commonly with multiplicities of receptors and binding sites-smart terminals. The morphological specializations and dynamic tuning of one-to-many efferent projections and many-to-one convergences of contacts onto afferents create a complex architecture capable of extensive peripheral integration in the brain-gut connectome and offset many of the disparities between axon and target numbers. Appreciating this complex architecture can help in the design of therapies for GI disorders.
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Registered trials
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