ArticleeLife2019
Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice.
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In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review).International journal of molecular medicine · 2024Pooled it
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- Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus.Molecular neurobiology · 2024Article
- Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity.iScience · 2024Article
- Agrin-Lrp4 pathway in hippocampal astrocytes restrains development of temporal lobe epilepsy through adenosine signaling.Cell & bioscience · 2024Article
- Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice.Cell death & disease · 2024Article
- The NDR family of kinases: essential regulators of aging.Frontiers in molecular neuroscience · 2024Review
- Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus.Journal of neuroinflammation · 2023Article
- Neural Isoforms of Agrin Are Generated by Reduced PTBP1-RNA Interaction Network Spanning the Neuron-Specific Splicing Regions inInternational journal of molecular sciences · 2023Article
- Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals.Nature communications · 2023Article
- Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.Frontiers in cell and developmental biology · 2023Article
- Bioinformatics-based analysis of the roles of basement membrane-related gene AGRN in systemic lupus erythematosus and pan-cancer development.Frontiers in immunology · 2023Article
- Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration.International journal of molecular sciences · 2022Review
- LRP4 is required for the olfactory association task in the piriform cortex.Cell & bioscience · 2022Article
- Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones.BMC biology · 2022Article
- Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4-FOXO1/SMS1 axis in sphingomyelin biosynthesis.Aging cell · 2021Article
- Timing and localization of myasthenia gravis-related gene expression.The European journal of neuroscience · 2021Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Hongsheng ZhangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.ORCID 0000-0001-8138-2108
Anupama SathyamurthyDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, United States.
Fang LiuDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, United States.
Lei LiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.
Lei ZhangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.
Zhaoqi DongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.
Wanpeng CuiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.
Xiangdong SunDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, United States.
Kai ZhaoDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, United States.
Hongsheng WangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.
Hsin-Yi Henry HoDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-8780-7864
Wen-Cheng XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.ORCID 0000-0001-9071-7598
Lin MeiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, United States.ORCID 0000-0001-5772-1229
Augusta University · USCase Western Reserve University · USHarvard University · US
Funding
Mechanisms of neuromuscular junction formationR01NS082007 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2013 to 2022
$5.2MNRG1-ErbB4 regulation of synaptic plasticity and behaviorR01MH083317 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2008 to 2018
$4.3MCharacterization of Agrin/LRP4 Antibody-Positive Myasthenia GravisR01NS090083 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2015 to 2019
$2.9MSwedish APP mutation and NMJ decline in Alzheimer's diseaseRF1AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2020 to 2020
$2.6MSwedish APP mutation and NMJ decline in Alzheimer's diseaseR01AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2015 to 2024
$2.6MRetromer deficiency and Alzheimer's disease pathologyRF1AG045781 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2019 to 2019
$2.0MDeciphering Wnt-Ror signaling in cytoskeletal regulation and tissue shape controlR35GM119574 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HO, HSIN-YI HENRY · 2016 to 2021
$2.0MAPP as a common denominator for Alzheimer's disease and osteoporosisR01AG051773 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2016 to 2020
$2.0MRetromer deficiency and Alzheimer's disease pathologyR01AG045781 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2014 to 2017
$1.7MNeuromuscular junction regenerationI01BX001020 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI MEI, LIN · 2014 to 2023
–BLRD VA I01 BX001020NIA NIH HHS R01 AG045781NIA NIH HHS R01 AG051510NIA NIH HHS R01 AG051773NIA NIH HHS RF1 AG045781NIA NIH HHS RF1 AG051510NIGMS NIH HHS R35 GM119574NIH HHS AG045781NIH HHS AG051510NIH HHS AG051773NIH HHS MH083317NIH HHS MH109280NIH HHS NS082007NIH HHS NS090083NIMH NIH HHS R01 MH083317NINDS NIH HHS R01 NS082007NINDS NIH HHS R01 NS090083
Abstract
Adult neurogenesis in the hippocampus may represent a form of plasticity in brain functions including mood, learning and memory. However, mechanisms underlying neural stem/progenitor cells (NSPCs) proliferation are not well understood. We found that Agrin, a factor critical for neuromuscular junction formation, is elevated in the hippocampus of mice that are stimulated by enriched environment (EE). Genetic deletion of the
Indexed as
NeurogenesisSignal TransductionAgrinAnimalsCell ProliferationGene Knockout TechniquesHippocampusLDL-Receptor Related ProteinsMiceNeural Stem CellsReceptor Tyrosine Kinase-like Orphan ReceptorsAgrinLDL-Receptor Related ProteinsLrp4 protein, mouseReceptor Tyrosine Kinase-like Orphan ReceptorsRor2 protein, mouseadult neurogenesisdepressive-like behaviorenriched environmentmouseneuroscience
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