Evidence map›Paper›PMID 31268371›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis.

Brett Ley, Dara G Torgerson, Justin M Oldham, Ayodeji Adegunsoye, Shuo Liu, Jie Li, Brett M Elicker, Travis S Henry, Jeffrey A Golden, Kirk D Jones and 6 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Prognostic biomarkers for the development of progressive pulmonary fibrosis in hypersensitivity pneumonitis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Guideline
  3. Guideline
  4. Review
  5. Review
  6. Review
  7. Observational
  8. Observational
  9. Genetic Familial Interstitial Lung Disease.Clinics in chest medicine · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Air pollution and alveolar health.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Brett LeyDepartment of Medicine.
Dara G TorgersonDepartment of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada.
Justin M OldhamDepartment of Medicine, University of California Davis, Davis, California.
Ayodeji AdegunsoyeDepartment of Medicine, University of Chicago, Chicago, Illinois.
Shuo LiuDepartment of Respiratory Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
Jie LiUniversity of California Davis Bioinformatics Core, Davis, California.
Brett M ElickerDepartment of Radiology and Biomedical Imaging.
Travis S HenryDepartment of Radiology and Biomedical Imaging.
Jeffrey A GoldenDepartment of Medicine.
Kirk D JonesDepartment of Pathology, and.
Amy DressenGenentech, South San Francisco, California; and.
Brian L YaspanGenentech, South San Francisco, California; and.
Joseph R ArronGenentech, South San Francisco, California; and.
Imre NothDepartment of Medicine, University of Virginia, Charlottesville, Virginia.
Thomas J HoffmannDepartment of Epidemiology and Biostatistics, Institute for Human Genetics, University of California San Francisco, San Francisco, California.
Paul J WoltersDepartment of Medicine.
University of California, Davis · USFourth Affiliated Hospital of China Medical University · CNMcGill University and Génome Québec Innovation Centre · CAUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Virginia · US

Funding

Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Lung Remodeling Mediated by Telomere Dysfunction in Alveolar Type II CellsR01HL139897 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Paul j WOLTERS · 2018 to 2026
$5.5M
Architectural structure and regulation of TOLLIP in IPFR01HL130796 · NHLBI · UNIVERSITY OF VIRGINIA · PI NOTH, IMRE · 2016 to 2019
$3.1M
Elucidating the Genomic Determinants of Outcomes in Idiopathic Pulmonary FibrosisK23HL138190 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLDHAM, JUSTIN M · 2017 to 2021
$914k
NCATS NIH HHS KL2 TR001870NHLBI NIH HHS K23 HL138190NHLBI NIH HHS R01 HL130796NHLBI NIH HHS R01 HL139897
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAlveolitis, Extrinsic AllergicCase-Control StudiesCell Cycle ProteinsCohort StudiesDNA HelicasesExoribonucleasesFemaleHumansMaleMiddle AgedMutationNuclear ProteinsRNAShelterin ComplexTelomeraseCell Cycle ProteinsDKC1 protein, humanDNA HelicasesExoribonucleasesNuclear ProteinsRNARTEL1 protein, humanShelterin ComplexTelomerasetelomerase RNATelomere-Binding ProteinsTERF1 protein, humanalveolitisextrinsic allergicprognosistelomere

Identifiers

PMID31268371
PMCPMC6888660
OpenAlexW2953589641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.