ArticleEnvironmental health perspectives2019
Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic.
Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between ambient air pollution exposure and pregnancy outcomes in women treated with assisted reproductive technology: an updated systematic review and meta-analysis.BMC public health · 2025Pooled it
- Critical Windows of Air Pollution Exposure During Spermatogenesis and Intrauterine Insemination Outcomes.Paediatric and perinatal epidemiology · 2026Article
- Impact of residential air pollution on in vitro fertilization (IVF) outcomes in New Jersey.Journal of assisted reproduction and genetics · 2026Article
- Effect of air pollution on clinical pregnancy outcomes following intrauterine insemination: a machine learning-based analysis.Frontiers in public health · 2026Article
- Maternal exposure to fine particulate matter and pregnancy outcomes in women undergoingEco-Environment & Health · 2025Article
- Assessing ambient air pollution's effects on birth outcomes: a Scottish IVF cohort study (2010 -2018).Environmental health : a global access science source · 2025Article
- Is air pollution a risk factor for early menopause?BMC public health · 2025Article
- Residential Exposure to PMPaediatric and perinatal epidemiology · 2025Article
- Clearing the Air on Reproductive Health: Unpacking the Impact of PMPaediatric and perinatal epidemiology · 2025Article
- Meta-analysis of studies testing the association between air pollution and live birth rates in women undergoing assisted reproductive technology.Toxicology research · 2025Review
- Associations of maternal PM2.5 exposure with preterm birth and miscarriage in women undergoingFrontiers in endocrinology · 2025Article
- Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality.Environment international · 2024Article
- Ambient air pollution and rate of spontaneous abortion.Environmental research · 2024Article
- Exposure to air pollution and ovarian reserve parameters.Scientific reports · 2024Article
- Association of ambient air pollutant mixtures with IVF/ICSI-ET clinical pregnancy rates during critical exposure periods.Human reproduction open · 2024Article
- Serum and follicular fluid metabolome and markers of ovarian stimulation.Human reproduction (Oxford, England) · 2023Article
- Air pollution and fecundability in a North American preconception cohort study.Environment international · 2023Article
- Associations between Residential Greenspace and Fecundability in a North American Preconception Cohort Study.Environmental health perspectives · 2023Article
- Effects of air pollution on clinical pregnancy rates after in vitro fertilisation (IVF): a retrospective cohort study.BMJ open · 2022Article
- Using follicular fluid metabolomics to investigate the association between air pollution and oocyte quality.Environment international · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundA few studies suggest that air pollution may decrease fertility, but prospective studies and examinations of windows of susceptibility remain unclear.
objectiveWe aimed to examine the association between time-varying exposure to nitrogen dioxide ([Formula: see text]), ozone ([Formula: see text]), fine particulate matter [Formula: see text] ([Formula: see text]), and black carbon (BC) on
methodsWe included 345 women (522 IVF cycles) for the [Formula: see text], [Formula: see text], and [Formula: see text] analyses and 339 women (512 IVF cycles) for the BC analysis enrolled in a prospective cohort at a Boston fertility center (2004–2015). We used validated spatiotemporal models to estimate daily residential exposure to [Formula: see text], [Formula: see text], [Formula: see text], and BC. Multivariable discrete time Cox proportional hazards models with four periods [ovarian stimulation (OS), oocyte retrieval to embryo transfer (ET), ET to implantation, implantation to live birth] estimated odds ratios (OR) and 95% confidence intervals (CI) of failing at IVF. Time-dependent interactions were used to identify vulnerable periods.
resultsAn interquartile range (IQR) increase in [Formula: see text], [Formula: see text], and BC throughout the IVF cycle was associated with an elevated odds of failing at IVF prior to live birth ([Formula: see text], 95% CI: 0.95, 1.23 for [Formula: see text]; [Formula: see text], 95% CI: 0.88, 1.28 for [Formula: see text]; and [Formula: see text], 95% CI: 0.96, 1.41 for BC). This relationship significantly varied across the IVF cycle such that the association with higher exposure to air pollution during OS was strongest for early IVF failures. An IQR increase in [Formula: see text], [Formula: see text], and BC exposure during OS was associated with 1.42 (95% CI: 1.20, 1.69), 1.26 (95% CI: 0.96, 1.67), and 1.23 (95% CI: 0.96, 1.59) times the odds of failing prior to oocyte retrieval, and 1.32 (95% CI: 1.13, 1.54), 1.27 (95% CI: 0.98, 1.65), and 1.32 (95% CI: 1.10, 1.59) times the odds of failing prior to ET.
conclusionIncreased exposure to traffic-related pollutants was associated with higher odds of early IVF failure. https://doi.org/10.1289/EHP4601.
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