Evidence map›Paper›PMID 31267722›Full record

ArticlePhysiological reports2019

Voluntary physical activity counteracts Chronic Heart Failure progression affecting both cardiac function and skeletal muscle in the transgenic Tgαq*44 mouse model.

Eleonora Bardi, Joanna Majerczak, Jerzy A Zoladz, Urszula Tyrankiewicz, Tomasz Skorka, Stefan Chlopicki, Magdalena Jablonska, Anna Bar, Krzysztof Jasinski, Alessia Buso and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eleonora BardiDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Joanna MajerczakDepartment of Muscle Physiology, Faculty of Rehabilitation, University School of Physical Education, Krakow, Poland.
Jerzy A ZoladzDepartment of Muscle Physiology, Faculty of Rehabilitation, University School of Physical Education, Krakow, Poland.
Urszula TyrankiewiczJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University Medical College, Krakow, Poland.
Tomasz SkorkaDepartment of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland.ORCID 0000-0002-7335-3072
Stefan ChlopickiJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University Medical College, Krakow, Poland.
Magdalena JablonskaDepartment of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland.
Anna BarJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University Medical College, Krakow, Poland.
Krzysztof JasinskiDepartment of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland.ORCID 0000-0002-6021-5674
Alessia BusoDepartment of Medicine, University of Udine, Udine, Italy.
Desy SalvadegoDepartment of Medicine, University of Udine, Udine, Italy.
Zenon NieckarzDepartment of Muscle Physiology, Faculty of Rehabilitation, University School of Physical Education, Krakow, Poland.
Bruno GrassiDepartment of Medicine, University of Udine, Udine, Italy.
Roberto BottinelliDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Maria Antonietta PellegrinoDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.ORCID 0000-0002-1653-1266

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity is emerging as an alternative nonpharmaceutical strategy to prevent and treat a variety of cardiovascular diseases due to its cardiac and skeletal muscle beneficial effects. Oxidative stress occurs in skeletal muscle of chronic heart failure (CHF) patients with possible impact on muscle function decline. We determined the effect of voluntary-free wheel running (VFWR) in preventing protein damage in Tgαq*44 transgenic mice (Tg) characterized by a delayed CHF progression. In the early (6 months) and transition (12 months) phase of CHF, VFWR increased the daily mean distance covered by Tg mice eliminating the difference between Tg and WT present before exercise at 12 months of age (WT Pre-EX 3.62 ± 1.66 vs. Tg Pre-EX 1.51 ± 1.09 km, P < 0.005; WT Post-EX 5.72 ± 3.42 vs. Tg Post-EX 4.17 ± 1.8 km, P > 0.005). This effect was concomitant with an improvement of in vivo cardiac performance [(Cardiac Index (mL/min/cm

Indexed as

RunningAnimalsCathepsin LFemaleHeartHeart FailureMiceMuscle ProteinsMuscle, SkeletalMyocardiumOxidative StressPhysical Conditioning, AnimalSKP Cullin F-Box Protein LigasesTripartite Motif ProteinsUbiquitin-Protein LigasesCathepsin LCtsl protein, mouseFbxo32 protein, mouseMuscle ProteinsSKP Cullin F-Box Protein LigasesTrim63 protein, mouseTripartite Motif ProteinsUbiquitin-Protein LigasesChronic heart failureoxidative stressvoluntary physical activity

Identifiers

PMID31267722
PMCPMC6606516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.