Trial reportBritish journal of haematology2019
Diagnosis of intravascular large B cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20 years.
Trial report in British journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 90 citations in OpenAlex.
- Diagnostic Predictive Model for Distinguishing Intravascular Large B-Cell Lymphoma Among Patients with Fever of Unknown Origin.Diagnostics (Basel, Switzerland) · 2026Article
- Adequacy of Single Random Skin Biopsy With Subcutaneous Sampling for the Diagnosis of Intravascular Lymphoma.Journal of cutaneous pathology · 2026Article
- Intravascular large B-cell lymphoma masked by multinodular goiter of the thyroid: a case report and diagnostic pitfall.Frontiers in oncology · 2026Article
- Beyond infection-a ferritin-LDH-IL-10 triad to unmask intravascular lymphoma in fever of unknown origin: a case report and literature review.Frontiers in medicine · 2026Article
- Intravascular Large B-Cell Lymphoma Presenting as Recurrent Cryptogenic Strokes: A Diagnostic Challenge.Case reports in hematology · 2026Article
- Recent advances in understanding and management of intravascular large B-cell lymphoma.Japanese journal of clinical oncology · 2025Review
- [Recurrent fever, persistent cytopenia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Review
- Magnetic resonance imaging findings of intravascular large B-cell lymphoma mimicking fasciitis of the thigh: A case report.Journal of clinical and experimental hematopathology : JCEH · 2025Article
- Clinical features and prognostic factors of intravascular large B-cell lymphoma: a cohort study of 20 patients from 2018 to 2024.The oncologist · 2025Article
- Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review.Journal of Zhejiang University. Science. B · 2025Review
- A Rare Case of Adrenal Intravascular Large B-Cell Lymphoma Diagnosed via Percutaneous Needle Biopsy.World journal of surgical oncology · 2025Article
- Prognostic factors of patients with intravascular large B cell lymphoma: a multicenter study in China.Frontiers in oncology · 2025Article
- Primary pulmonary intravascular large B‑cell lymphoma: Indications from cytomorphology findings through CT‑guided puncture: A case report.Oncology letters · 2025Article
- Clinicopathological characteristics, prognostic factors, and outcomes of elderly patients with lymphoma-associated hemophagocytic lymphohistiocytosis: A multicenter analysis.Cancer medicine · 2024Article
- Neurolymphomatosis secondary to primary central nervous system lymphoma: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Optimizing random skin biopsies: a review of techniques and indications for intravascular large B-cell lymphoma.International journal of hematology · 2024Review
- Article
- Intravascular Large B-cell Lymphoma Presenting as Pulmonary Ground-glass Nodules That Progressed Slowly over Several Months with No Overt Symptoms.Internal medicine (Tokyo, Japan) · 2024Article
- Intravascular large B-cell lymphoma with respiratory failure diagnosed by random skin biopsy: A case report.Respiratory medicine case reports · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to clarify the comprehensive clinical, laboratory, pathological and imaging features of intravascular large B-cell lymphoma (IVLBCL) using data on 42 IVLBCL patients diagnosed at our hospital over the past 20 years. The majority of patients were diagnosed via random skin biopsy (29/42, 69·0%) followed by bone marrow biopsy alone (8/42, 19·0%). Characteristic features included persistent fever (41/42, 97·6%), decreased performance status (≥2) (100%), hypoxaemia (32/40, 80·0%), impaired consciousness (19/42, 45·2%), hypoalbuminemia (42/42, 100%) and extreme elevation of lactate dehydrogenase and soluble interleukin 2 receptor levels. Brain magnetic resonance imaging showed abnormal findings in 32/37 patients (86·4%). Hyperintense lesion in the pons was a peculiar finding that was unrelated to the neurological deficits. Positron emission tomography-computed tomography revealed a high incidence of bone marrow (26/34, 76·5%), spleen (19/34, 55·9%) and adrenal gland (9/34, 26·5%) involvement. Neurolymphomatosis was noted in 6 patients during the course of the disease. About 60% of IVLBCL patients in whom in vivo diagnosis was possible survived more than 5 years with combination chemotherapy. Our observations provide additional insight into the diagnosis of IVLBCL and indicate that early disease recognition via random skin biopsy combined with imaging, enables in vivo diagnosis of the disease and improved survival for many patients.
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