Evidence map›Paper›PMID 31267470›Full record

ReviewClinical reviews in allergy & immunology2020

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases.

Fereshte Abdolmaleki, Petri T Kovanen, Rajab Mardani, Seyed Mohammad Gheibi-Hayat, Simona Bo, Amirhossein Sahebkar

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  5. Article
  6. Article
  7. Lipid metabolism in homeostasis and disease.Signal transduction and targeted therapy · 2026
    Review
  8. Article
  9. Comprehensive Plasma Oxylipin Profiling Reveals a Pro-Inflammatory Eicosanoid Signature and Diagnostic Biomarker Panel in Dilated Cardiomyopathy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  10. Article
  11. Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Diet type and the oral microbiome.Frontiers in nutrition · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Fereshte AbdolmalekiCellular and Molecular Research Center, School of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran.
Petri T KovanenWihuri Research Institute, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2532-367X
Rajab MardaniDepartment of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
Seyed Mohammad Gheibi-HayatDepartment of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Simona BoDepartment of Medical Sciences, AOU Città della Salute e della Scienza di Torino, University of Turin, Torino, Italy.
Amirhossein SahebkarNeurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
Mashhad University of Medical Sciences · IRPasteur Institute of Iran · IRQazvin University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IRUniversity of Turin · ITWihuri Research Institute · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are metabolic products of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of neutrophil infiltration, stimulation of the clearance of apoptotic cells by macrophages, and promotion of tissue remodeling and homeostasis. Metabolic dysregulation due to either uncontrolled activity of pro-inflammatory responses or to inefficient resolution of inflammation results in chronic inflammation and may also lead to atherosclerosis or other chronic autoimmune diseases such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus, vasculitis, inflammatory bowel diseases, and type 1 diabetes mellitus. The pathogenesis of such diseases involves a complex interplay between the immune system and, environmental factors (non-infectious or infectious), and critically depends on individual susceptibility to such factors. In the present review, resolvins and their roles in the resolution of inflammation, as well as the role of these mediators as potential therapeutic agents to counteract specific chronic autoimmune and inflammatory diseases are discussed.

Indexed as

Disease SusceptibilityAnimalsAutoimmune DiseasesBiomarkersBiosynthetic PathwaysFatty Acids, UnsaturatedHumansInflammationInflammation MediatorsLipid MetabolismBiomarkersFatty Acids, UnsaturatedInflammation MediatorsAutoimmune diseasesResolution of inflammationResolvinsSpecialized pro-resolving mediators

Identifiers

PMID31267470
OpenAlexW2954839565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.