Evidence map›Paper›PMID 31267358›Full record

ReviewDiabetes therapy : research, treatment and education of diabetes and related disorders2019

Glucocrinology of Modern Sulfonylureas: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

Sanjay Kalra, A K Das, M P Baruah, A G Unnikrishnan, Arundhati Dasgupta, Parag Shah, Rakesh Sahay, Rishi Shukla, Sambit Das, Mangesh Tiwaskar and 34 more

Open access · goldAbstract readReview
In one paragraph

Review in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 17 countries.

Sanjay KalraDepartment of Endocrinology, Bharti Hospital and BRIDE, Karnal, Haryana, India. brideknl@gmail.com.
A K DasDepartment of Endocrinology and Medicine, Pondicherry Institute of Medical Sciences, Puducherry, India.
M P BaruahDepartment of Endocrinology, Excel Hospital, Guwahati, Assam, India.
A G UnnikrishnanDepartment of Endocrinology and Diabetes, Chellaram Diabetes Institute, Pune, Maharashtra, India.
Arundhati DasguptaDepartment of Endocrinology, Rudraksh Superspecialty Care, Siliguri, India.
Parag ShahDepartment of Endocrinology and Diabetes, Gujarat Endocrine Centre, Ahmedabad, India.
Rakesh SahayDepartment of Endocrinology, Osmania Medical College, Hyderabad, India.
Rishi ShuklaDepartment of Endocrinology, Regency Hospital Ltd., Kanpur, India.
Sambit DasDepartment of Endocrinology, Apollo Hospitals, Bhubaneswar, India.
Mangesh TiwaskarDepartment of Diabetology, Shilpa Medical Research Centre, Mumbai, India.
G VijayakumarDepartment of Diabetology, Apollo Hospitals, Chennai, India.
Manoj ChawlaDepartment of Diabetology, Lina Diabetes Care and Mumbai Diabetes Research Centre, Mumbai, India.
Fatimah ElianaDepartment of Internal Medicine, Faculty of Medicine, YARSI University, Jakarta, Indonesia.
Ketut SuastikaIndonesian Association of Endocrinology, Jakarta, Indonesia.
Abbas OrabiDepartment of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Aly Ahmed Abdul RahimDepartment of Diabetes and Metabolism, Alexandria University, Alexandria, Egypt.
Andrew UlokoDepartment of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
Silver BahendekaDepartment of Internal Medicine, Diabetes and Endocrinology, St. Francis Hospital, Nsambya, Kampala, Uganda.
Abdurezak Ahmed AbdelaDepartment of Internal Medicine, Addis Ababa, Ethiopia.
Fariduddin MohammedDepartment of Endocrinology of Bangabandhu Sheikh, Mujib Medical University, Dhaka, Bangladesh.
Faruque PathanDepartment of Endocrinology, Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh.
Muhammed Hafizur RahmanDepartment of Endocrinology, Dhaka Medical College and Hospital, Dhaka, Bangladesh.
Faria AfsanaDepartment of Endocrinology, Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh.
Shajada SelimDepartment of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Muaz MoosaDepartment of Internal Medicine, Indira Gandhi Memorial Hospital, Malé, Maldives.
Moosa MuradDepartment of Internal Medicine, Indira Gandhi Memorial Hospital, Malé, Maldives.
Pradeep Krishna ShreshthaDepartment of Internal Medicine, Tribhuwan University Teaching Hospital, Kathmandu, Nepal.
Dina ShreshthaDepartment of Endocrinologist, Norvic International Hospital, Kathmandu, Nepal.
Mimi GiriDepartment of Endocrinology, Nepal Mediciti Hospital, Kathmandu, Nepal.
Wiam HussainDepartment of Endocrinology and Diabetes, Dr Wiam Clinic, Royal Hospital, Awali Hospital, Awali, Bahrain.
Ahmed Al-AniDepartment of Internal Medicine, Hamad Hospital, Doha, Qatar.
Kaushik RamaiyaDepartment of Diabetology, Shree Hindu Mandal Hospital, Dar es Salaam, Tanzania.
Surender SinghDepartment of Internal Medicine, Aster Al Raffah Hospital, Muscat, Oman.
Syed Abbas RazaDepartment of Endocrinology, Shaukat Khanum Hospital and Research Center, Lahore, Pakistan.
Than Than AyeMyanmar Society of Endocrinology and Metabolism, Yangon, Myanmar.
Chaminda GarusingheDepartment of Endocrinology, Colombo South Teaching Hospital, Colombo, Sri Lanka.
Dimuthu MuthukudaDepartment of Endocrinology, Sri Jayawardenepura General Hospital, Sri Jayawardenepura Kotte, Sri Lanka.
Muditha WeerakkodyDepartment of Endocrinology, Teaching Hospital Karapitiya, Galle, Sri Lanka.
Shyaminda KahandawaDepartment of Endocrinology, District General Hospital, Matara, Sri Lanka.
Charlotte BavumaDepartment of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Rwanda.
Sundeep RuderDepartment of Endocrinology and Metabolism, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
Koy VannyDepartment of Diabetes and Endocrinology, Dr Koy Vanny Diabetes and Endocrine Clinic, Phnom Penh, Cambodia.
Manish KhanolkarDepartment of Endocrinology and Diabetes, Waikato Hospital, Hamilton, New Zealand.
Leszek CzupryniakDepartment of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders · BDBangladesh Medical University · BDIndira Gandhi Memorial Hospital · MVAddis Ababa University · ETAga Khan Hospital Dar es Salaam · TZAlexandria University · EGAminu Kano Teaching Hospital · NGApollo Hospitals · INApollo Hospitals · INBharti Hospital · INColombo North Teaching Hospital · LKDhaka Medical College and Hospital · BDGrande International Hospital · NPHamad General Hospital · QAJohannesburg Hospital · ZAMedical University of Warsaw · PLNepal Medical College Teaching Hospital · NPNsambya Hospital · UGOsmania Medical College · INPondicherry Institute of Medical Sciences · IN

Funding

Sanofi India 00
6 · The paper itself

Abstract

aimThe primary objective of this document is to develop practice-based expert group opinion on certain important but less discussed endocrine and metabolic effects of modern sulfonylureas (SUs) and their usage in the management of diabetes mellitus (DM).

backgroundModern SUs may be considered a panacea in DM care with their beneficial extra-pancreatic, pleiotropic, and cardiovascular effects. Safe glycemic control with SUs could be achieved with appropriate patient selection, drug and dosage selection, and patient empowerment. Additionally, sulfonylureas also exhibit certain endocrine and metabolic effects, which could be considered beneficial in the management of DM. In this regard, a group of international clinical experts discussed the less known beneficial aspects of SUs and safe and smart prescription of modern SUs in DM care.

resultsThe concept of glucocrinology or the relationship of glycemia with the endocrine system was emphasized during the meetings. Clinical experts arrived at a consensus for the usage of modern SUs in the presence of other endocrine dysfunction and the impact of these drugs on endocrine health. The beneficial pleiotropic and cardiovascular effects of modern SUs were also discussed. The key discussion points were considered to develop clinical expert opinions for the use of modern SUs in persons with DM. Clinical expert opinions were developed for indications, pleiotropic benefits, cardiovascular outcomes, adherence, and safe use of modern SUs.

conclusionsAppropriate clinical judgement coupled with a patient-centered approach is crucial to achieve the best outcome in persons with DM. Owing to their safety, efficacy, extra-pancreatic benefits including effects on endocrine and metabolic aspects, and low cost of therapy, modern SUs could be considered as drugs/agents of choice for the treatment of diabetes.

fundingSanofi India.

Indexed as

Cardiovascular complicationsCardiovascular phenotypeExtra-pancreatic effectsGlimepirideGlucocrinologyModern sulfonylureasMyocardial ischemic preconditioningType 2 diabetes mellitus

Identifiers

PMID31267358
PMCPMC6778594
OpenAlexW2954211143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.