Evidence map›Paper›PMID 31267180›Full record

ArticleWorld journal of urology2020

Manganese dioxide coating reduces bacterial adhesion and infection in silicon implants in animal model.

Lucas Mira Gon, Caio César Citatini de Campos, Eduardo Riccetto, Carlos Emílio Levy, Osvaldo Griguol, Cássio Luís Zanettini Riccetto

Abstract read
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In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lucas Mira GonDivision of Urology, Department of Surgery, Faculty of Medical Sciences, University of Campinas, UNICAMP, Rua Vital Brazil, 250, Campinas, SP, 13083-590, Brazil. lucasmgon@gmail.com.ORCID http://orcid.org/0000-0002-4686-2138
Caio César Citatini de CamposDivision of Urology, Department of Surgery, Faculty of Medical Sciences, University of Campinas, UNICAMP, Rua Vital Brazil, 250, Campinas, SP, 13083-590, Brazil.
Eduardo RiccettoFaculty of Medical Sciences, University of Campinas, UNICAMP, Campinas, Brazil.
Carlos Emílio LevyDivision of Microbiology of Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, UNICAMP, Campinas, Brazil.
Osvaldo GriguolResearch and Development Department, Ferreyra Industrial Park, Promedon, Córdoba, Argentina.
Cássio Luís Zanettini RiccettoDivision of Urology, Department of Surgery, Faculty of Medical Sciences, University of Campinas, UNICAMP, Rua Vital Brazil, 250, Campinas, SP, 13083-590, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRInstituto de Investigación Médica Mercedes y Martín Ferreyra · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo propose a new coating to silicone implants using Manganese dioxide. We present bacterial adhesion and proliferation when implants are challenged with Escherichia coli.

methodsCoated and control silicon implants were placed in two independent subcutaneous pouches in the dorsum of Wistar rats. After skin closure, 0.5 ml of E. coli solution was injected in each incision. The animals were euthanized at 7 and 28 days. Extracted material was cultured and analyzed by confocal microscopy.

resultsAt 1 week, uncoated implants had a 17-fold higher infection rate (p < 0.001). Coated samples showed a mean bacterial count of 28,700 CFU/ml, while the control ones 503,000 CFU/ml, with a significant mean difference of 474,300 CFU/ml (95% CI 165,900-782,600). At 4 weeks, the mean bacterial growth in coated group was 7600; while in control one was 53,890. The mean difference between groups was 46,200 (95% CI 21,100-71,400). Confocal microscopy presented the percentage of implant's surface with attached bacteria: at 7 days, coated implants had 6.85% and controls 10.9% and the difference was not significant (p =0.32). At 4 weeks, the coated group showed 0.98% of the surface with attached bacteria, while control group showed 7.64%, which resulted in a significant 11-fold difference (p = 0.004).

conclusionsManganese dioxide coating inhibits bacterial proliferation and adhesion in subcutaneous silicon implants in an animal model. These findings can be useful to improve development of biomaterials.

Indexed as

SiliconesAnimalsBacterial AdhesionBacterial LoadCoated Materials, BiocompatibleEscherichia coliEscherichia coli InfectionsManganese CompoundsMicroscopy, ConfocalOxidesProstheses and ImplantsProsthesis-Related InfectionsRatsRats, WistarCoated Materials, BiocompatibleManganese Compoundsmanganese dioxideOxidesSiliconesExperimental animal modelsExperimental implantsInfectionSiliconSurface-coated materials

Identifiers

PMID31267180
OpenAlexW2955007228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.