Evidence map›Paper›PMID 31267143›Full record

ArticlePediatric surgery international2019

Development of a new reproductive tissue cryopreservation clinical service for children: the Oxford programme.

K Lakhoo, J Davies, S Chakraborty, S Berg, R Tennyson, D Fowler, S Manek, C Verrill, S Lane

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Article in Pediatric surgery international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

K LakhooDepartment of Paediatric Surgery, University of Oxford and Oxford University Hospitals, Oxford, UK. Kokila.lakhoo@nds.ox.ac.uk.ORCID http://orcid.org/0000-0003-1840-708X
J DaviesOxford Tissue Bank, University of Oxford and Oxford University Hospitals, Oxford, UK.
S ChakrabortyDepartment of Paediatric Radiology, University of Oxford and Oxford University Hospitals, Oxford, UK.
S BergDepartment of Paediatric Anaesthesia, University of Oxford and Oxford University Hospitals, Oxford, UK.
R TennysonDepartment of Psychology, University of Oxford and Oxford University Hospitals, Oxford, UK.
D FowlerDepartment of Cellular Pathology, University of Oxford and Oxford University Hospitals, Oxford, UK.
S ManekDepartment of Cellular Pathology, University of Oxford and Oxford University Hospitals, Oxford, UK.
C VerrillDepartment of Cellular Pathology, University of Oxford and Oxford University Hospitals, Oxford, UK.
S LaneDepartment of Paediatrics and Child Health, University of Oxford and Oxford University Hospitals, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis article describes the development of a new reproductive tissue cryopreservation clinical service for children at high risk of infertility in the NHS during times of severe financial constraints in the health service.

methodA development plan with two phases was drawn up. Phase 1 restricted the service to childhood cancer patients referred to the Oxford Paediatric Oncology and Haematology Principle Treatment Centre. It was estimated that there would be 10 patients/year and used existing staff and facilities from paediatric oncology, surgery, anaesthetics radiology, pathology, psychology, teenage-young adult gynaecology, and an existing Human Tissue Authority tissue bank with a licence for storage of tissue under a Human Sector Licence. Phase 2 extended the service to include children and young adults across England, Wales and Ireland-patients from Scotland having access to a research programme in Edinburgh. The main challenge in phase 2 being resources and the need for patients to be able to be treated as close to home as safely as possible.

resultsThe Oxford team developed information resources and eligibility criteria based on published best practice, referral and treatment pathways, multidisciplinary team meetings, a network of third party sites, and a dedicated case management and database. As the programme expanded, the Oxford team was able to justify to management the need for a dedicated theatre list. Patient feedback through questionnaires, qualitative work conducted as part of a Ph.D. thesis as well as direct patient stories and interviews in TV, and radio features underpins the positive impact the programme has on patients and their families.

conclusionThe Oxford Reproductive Cryopreservation programme delivers fertility preservation treatment to children and young adults at high risk of infertility safely, effectively and as close to home as possible. The onward view is to apply for national funding for this programme for recognition and sustainability.

Indexed as

CryopreservationFertility PreservationOvarySpermatogoniaTestisTissue BanksAdolescentChildFemaleHumansMaleNeoplasmsOvariectomyUnited KingdomYoung AdultChildrenCryopreservationOvaryPremature ovarian and testicular insufficiencyReproductive tissueTestisYoung adults

Identifiers

PMID31267143
PMCPMC6800834

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.