ArticleEye (London, England)2019
Retinal pigment epithelium apertures as a late complication of longstanding serous pigment epithelium detachments in chronic central serous chorioretinopathy.
Article in Eye (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Correlation Between RPE Aperture and Photoreceptor Integrity in Non-Neovascular AMD: A Longitudinal Study Using OCT and 3D Morphological Analysis.Translational vision science & technology · 2026Article
- Acute central serous chorioretinopathy with enlarging retinal pigment epithelium microrip.Eye (London, England) · 2026Article
- PHOTOBIOMODULATION THERAPY FOR SEROUS PIGMENT EPITHELIUM DETACHMENT IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY.Retinal cases & brief reports · 2025Article
- Non-exudative OCT findings in neovascular AMD.Eye (London, England) · 2025Review
- Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years.Investigative ophthalmology & visual science · 2024Article
- En Face Choroidal Vascularity in Both Eyes of Patients with Unilateral Central Serous Chorioretinopathy.Journal of clinical medicine · 2022Article
- Comment on: 'Retinal pigment epithelium apertures as a late complication of longstanding serous pigment epithelium detachments in chronic central serous chorioretinopathy'.Eye (London, England) · 2022Article
- Clinical features of cases with retinal pigment epithelium aperture.American journal of ophthalmology case reports · 2021Article
- Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography.Japanese journal of ophthalmology · 2021Article
- Healing pattern of subfoveal retinal pigment epithelium rip and aperture in central serous chorioretinopathy.Oman journal of ophthalmologyArticle
- Fundus Autofluorescence and Clinical Applications.Journal of ophthalmic & vision researchReview
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo report retinal pigment epithelium (RPE) apertures as a possible evolution of serous pigment epithelium detachment (PED) in patients with chronic central serous chorioretinopathy (CSC) and to analyze their progression over time.
designRetrospective case series.
methodsFifteen patients (17 eyes) with a diagnosis of avascular PED in chronic CSC were retrospectively evaluated based on multimodal imaging. All patients had documented records of clinical examination, best correct visual acuity (BCVA), fundus autofluorescence (FAF), fluorescein and indocyanine green angiography, spectral-domain optical coherence tomography, and optical coherence tomography angiography (OCT-A). Primary outcomes measures were RPE aperture imaging analysis along with their temporal course.
resultsAll eyes showed the RPE aperture as an interruption of the RPE in correspondence of the PED with neither sign of rippling nor retraction. Mean age was 59.4 ± 8.1 years and mean BCVA was 0.34 ± 0.24 logMAR. In all eyes, FAF displayed a well-circumscribed roundish hypoautofluorescence. Multimodal imaging and OCT-A confirmed the absence of any vascular network beneath the aperture in all study eyes. The mean time of follow-up was 19.3 ± 14.3 months, and RPE discontinuities showed an increase in size over time from 0.81 ± 0.39 mm
conclusionsRPE aperture is a new finding in the setting of chronic CSC and it should be distinguished by RPE tears for the different pathogenesis and evolution in time.
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